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2-Bromo-4-butanolide

2-Bromo-4-butanolide Structure
2-Bromo-4-butanolide structure
CAS No.
5061-21-2
Chemical Name:
2-Bromo-4-butanolide
Synonyms
3-Bromodihydrofuran-2(3H)-one;α-Bromo-γ-butyrolactone;3-Bromotetrahydrofuran-2-one;3-Bromdihydrofuran-2(3H)-on;AKOS 23;à-bromo-;NSC 11726;NSC 56959;α-Bromo-γ-butyroL;3-Bromo-2-furanone
CBNumber:
CB0139728
Molecular Formula:
C4H5BrO2
Molecular Weight:
164.99
MDL Number:
MFCD00005387
MOL File:
5061-21-2.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:46
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2-Bromo-4-butanolide Properties

Boiling point 138 °C/6 mmHg (lit.)
Density 1.786 g/mL at 25 °C (lit.)
refractive index n20/D 1.508(lit.)
Flash point >230 °F
storage temp. Inert atmosphere,2-8°C
solubility Acetone, Chloroform, Ethyl Acetate, Methanol
form Clear Colourless to Light Yellow Liquid
Specific Gravity 1.778 (20/4℃)
Appearance Colorless to light yellow Liquid
Sensitive Moisture Sensitive/Lachrymatory
BRN 107800
InChI InChI=1S/C4H5BrO2/c5-3-1-2-7-4(3)6/h3H,1-2H2
InChIKey LFJJGHGXHXXDFT-UHFFFAOYSA-N
SMILES O1CCC(Br)C1=O
CAS DataBase Reference 5061-21-2(CAS DataBase Reference)
NIST Chemistry Reference 2(3H)-Furanone, 3-bromodihydro-(5061-21-2)
EPA Substance Registry System 2(3H)-Furanone, 3-bromodihydro- (5061-21-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN 2810
WGK Germany  3
F  21
Hazard Note  Irritant/Keep Cold/Lachrymatory/Moisture Sensitive
TSCA  Yes
HS Code  29322980
NFPA 704
1
1 0

2-Bromo-4-butanolide price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B59608 α-Bromo-γ-butyrolactone 97% 5061-21-2 25g $101 2025-07-31 Buy
Sigma-Aldrich B59608 α-Bromo-γ-butyrolactone 97% 5061-21-2 100g $359 2025-07-31 Buy
TCI Chemical B1228 alpha-Bromo-gamma-butyrolactone >95.0%(GC) 5061-21-2 25g $42 2025-07-31 Buy
TCI Chemical B1228 alpha-Bromo-gamma-butyrolactone >95.0%(GC) 5061-21-2 500g $493 2025-07-31 Buy
TRC B682070 α-Bromo-γ-butyrolactone 5061-21-2 10g $45 2021-12-16 Buy
Product number Packaging Price Buy
B59608 25g $101 Buy
B59608 100g $359 Buy
B1228 25g $42 Buy
B1228 500g $493 Buy
B682070 10g $45 Buy

2-Bromo-4-butanolide Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Liquid

Uses

Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1.

Synthesis

Gamma Butyrolactone

96-48-0

2-Bromo-4-butanolide

5061-21-2

General procedure for the synthesis of α-bromo-γ-butyrolactone from γ-butyrolactone (bromination step): in a 1000 mL reaction vessel equipped with a stirring device, refluxing device, thermometer, dropping funnel, and nitrogen introduction tube, 200 g (2.32 mol) of γ-butyrolactone and 2.76 g (0.086 mol based on 3.7 mol% of γ-butyrolactone) of sulfur were added as the catalyst. 431 g (2.70 mol) of bromine was loaded into a dropping funnel. Stirring was initiated, the reaction temperature was controlled not to exceed 40 °C, and the bromine was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was raised to about 90 °C and the reaction was maintained at this temperature for 1 hour. Subsequently, the temperature was raised to about 110°C and the reaction was continued for 3 hours.

References

[1] Patent: JP5837752, 2015, B2. Location in patent: Paragraph 0052; 0079-0081; 0082; 0085; 0086; 0088
[2] Journal of Porphyrins and Phthalocyanines, 2010, vol. 14, # 1, p. 89 - 100
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3074 - 3077
[4] Synlett, 2005, # 17, p. 2648 - 2652
[5] Organic Letters, 2011, vol. 13, # 14, p. 3670 - 3673

2-Bromo-4-butanolide synthesis

96-48-0
5061-21-2
Synthesis of 2-Bromo-4-butanolide from Gamma Butyrolactone

2-Bromo-4-butanolide Preparation Products And Raw materials

Raw materials

Government regulation Gamma Butyrolactone

Preparation Products

SPIZOFURONE 2-Oxotetrahydrofuran-3-yl methacrylate ALPHA-HEXYL-GAMMA-BUTYROLACTONE

2-Bromo-4-butanolide Suppliers

Global( 398)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8617732866630 abby@chuanghaibio.com China 8773 58
Hebei Mujin Biotechnology Co.,Ltd 		+86-13288715578 sales@hbmojin.com China 12648 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
RongNa Biotechnology Co.,Ltd 		+86-86-13583358881 +8618560316533 Brad@rongnabiotech.com China 3060 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Anhui Yiao New Material Technology Co., Ltd 		+86-18033737140 +86-17354101231 sales1@hbganmiao.com China 227 58
Xiamen Wonderful Bio Technology Co., Ltd. 		+8613043004613 Sara@xmwonderfulbio.com China 283 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20202 58
Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 sales8@hbganmiao.com China 300 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29731 60
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
RongNa Biotechnology Co.,Ltd 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Anhui Yiao New Material Technology Co., Ltd 		58
Xiamen Wonderful Bio Technology Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Ganmiao New material Technology Co., LTD 		58
Capot Chemical Co.,Ltd. 		60

View Lastest Price from 2-Bromo-4-butanolide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-4-butanolide pictures 2025-08-04 2-Bromo-4-butanolide
5061-21-2
 US $1.00 / g 1g 99% 1000kg RongNa Biotechnology Co.,Ltd
2-Bromo-4-butanolide pictures 2025-07-29 2-Bromo-4-butanolide
5061-21-2
 US $0.00 / kg 1kg 0.99 10T Shandong Hanjiang Chemical Co., Ltd
2-Bromo-4-butanolide pictures 2025-07-25 2-Bromo-4-butanolide
5061-21-2
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2-Bromo-4-butanolide Spectrum

2-Bromo-4-butanolide(5061-21-2)MS2-Bromo-4-butanolide(5061-21-2)1HNMR2-Bromo-4-butanolide(5061-21-2)13CNMR2-Bromo-4-butanolide(5061-21-2)IR12-Bromo-4-butanolide(5061-21-2)Raman

5061-21-2(2-Bromo-4-butanolide)Related Search:

BETA-BUTYROLACTONE TRIOXSALEN Tungsten p-Toluenesulfonic acid Citric acid
Dimethyl sulfoxide Sodium carbonate Zinc oxide Manganese dioxide Diethylstilbestrol
Bromine Gamma Butyrolactone ALPHA-BROMO-ALPHA-METHYL-GAMMA-BUTYROLACTONE ALPHA-BROMO-GAMMA-VALEROLACTONE 2-Bromo-4-butanolide
SALOR-INT L132004-1EA A-BROMO-A-TRIFLUOROACETYL-G-BUTYROLACTONE, HYDRATE

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2-BROMO-GAMMA-BUTYROLACTONE 2-BROMO-Y-BUTYROLACTONE 2-bromo-4-butanolide 2-BROMO-4-HYDROXYBUTYRIC ACID GAMMA-LACTONE 2-BROMO-4-HYDROXYBUTYRIC ACID LACTONE BROMO(ALPHA-)-GAMMA-BUTYROLACTONE 2-Bromo-4-butyrolactone 2-Bromobutyrolactone 3-bromodihydro-2(3h)-furanon 3-Bromodihydro-2(3H)-furanone 3-Bromodihydro-2-furanone alpha-Bromobutyric acid, gamma-lactone alpha-Bromobutyrolactone -Bromo-butyrolactone A-BROMO-GAMMA-BUTYROLACTONE A-BROMO-G-BUTYROLACTONE AKOS 23 ALPHA-BROMO-GAMMA-BUTYROLACETONE ALPHA-BROMO-GAMMA-BUTYROLACTONE __bromo-r-butyrolactone 2(3H)-Furanone, 3-bromodihydro- 2-Bromo-4-hydroxybutyric acid g-lactone 3-Bromo-4,5-dihydro-2(3H)-furanone alpha-Bromo-gamma-butyrolactone, remainder gamma-butyrolactone alpha-Bromo-gama-butyrolactone 2-Bromo-c-butyrolactone A-BROMO-γ-BUTYROLATONE Alpha-Bromo-Gamma-Butyrolactone95+% Alpha-Bromo-Gama-Butyrolatone alpha-Bromo-gamma-butyrolactone,97% alpha-Bromo-gamma-butyrolactone, ca. 90% à-bromo- A-BROMO--BUTYROLACTONE A-BROMO-R-BUTYROLATONE ɑ-Bromo-γ-butyrolactone, 97% NSC 11726 NSC 56959 3-Bromo-2-furanone ^a-Bromo-^y-butyrolactone, 97% α-Bromo-γ-butyrolactone,2-Bromo-4-hydroxybutyric acid γ-lactone 3-Bromo-dihydro-furan-2-one |á-Bromo-|-butyrolactone α-Bromo-γ-butyrolatone Alpha-BroMo-GaMMa-ButyrolaCLone 2-broMo-4-hydroxybutan-1-ide alpha-Bromo-gamma-butyrolactone 97% 2-Bromo-γ-butyrolactone for synthesis 2-Bromo-4-hydroxybutyric acid 2-Bromo-4-butanolide in stock Factory 3-Bromodihydrofuran-2(3H)-one 95+% α-Bromo-γ-butyroL α-Bromo-γ-butyrolactone> α-Bromo-γ-butanolide 3-Bromodihydrofuran-2(3H)-one 3-Bromotetrahydrofuran-2-one 3-Bromdihydrofuran-2(3H)-on α-Bromo-γ-butyrolactone α-Bromo-γ-butyrolactone