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2-Bromo-4-butanolide

2-Bromo-4-butanolide structure

CAS No.: 5061-21-2

Chemical Name:: 2-Bromo-4-butanolide

Synonyms: 3-Bromodihydrofuran-2(3H)-one;α-Bromo-γ-butyrolactone;3-Bromotetrahydrofuran-2-one;3-Bromdihydrofuran-2(3H)-on;AKOS 23;à-bromo-;NSC 11726;NSC 56959;α-Bromo-γ-butyroL;3-Bromo-2-furanone

CBNumber:: CB0139728

Molecular Formula:: C4H5BrO2

Molecular Weight:: 164.99

MDL Number:: MFCD00005387

MOL File:: 5061-21-2.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:03

Product description	Number	Pack Size	Price
α-Bromo-γ-butyrolactone 97%	B59608	25g	$101
α-Bromo-γ-butyrolactone 97%	B59608	100g	$359
alpha-Bromo-gamma-butyrolactone >95.0%(GC)	B1228	25g	$42
alpha-Bromo-gamma-butyrolactone >95.0%(GC)	B1228	500g	$493
α-Bromo-γ-butyrolactone	B682070	10g	$45
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2-Bromo-4-butanolide Properties

Boiling point	138 °C/6 mmHg (lit.)
Density	1.786 g/mL at 25 °C (lit.)
refractive index	n20/D 1.508(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,2-8°C
solubility	Acetone, Chloroform, Ethyl Acetate, Methanol
form	Clear Colourless to Light Yellow Liquid
Specific Gravity	1.778 (20/4℃)
Appearance	Colorless to light yellow Liquid
Sensitive	Moisture Sensitive/Lachrymatory
BRN	107800
InChI	InChI=1S/C4H5BrO2/c5-3-1-2-7-4(3)6/h3H,1-2H2
InChIKey	LFJJGHGXHXXDFT-UHFFFAOYSA-N
SMILES	O1CCC(Br)C1=O
CAS DataBase Reference	5061-21-2(CAS DataBase Reference)
NIST Chemistry Reference	2(3H)-Furanone, 3-bromodihydro-(5061-21-2)
EPA Substance Registry System	2(3H)-Furanone, 3-bromodihydro- (5061-21-2)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN 2810

WGK Germany

Hazard Note

Irritant/Keep Cold/Lachrymatory/Moisture Sensitive

TSCA

TSCA listed

HS Code

29322980

Storage Class

10 - Combustible liquids

NFPA 704

	1
1		0

2-Bromo-4-butanolide price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B59608	α-Bromo-γ-butyrolactone 97%	5061-21-2	25g	$101	2025-07-31	Buy
Sigma-Aldrich	B59608	α-Bromo-γ-butyrolactone 97%	5061-21-2	100g	$359	2025-07-31	Buy
TCI Chemical	B1228	alpha-Bromo-gamma-butyrolactone >95.0%(GC)	5061-21-2	25g	$42	2025-07-31	Buy
TCI Chemical	B1228	alpha-Bromo-gamma-butyrolactone >95.0%(GC)	5061-21-2	500g	$493	2025-07-31	Buy
TRC	B682070	α-Bromo-γ-butyrolactone	5061-21-2	10g	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
B59608	25g	$101	Buy
B59608	100g	$359	Buy
B1228	25g	$42	Buy
B1228	500g	$493	Buy
B682070	10g	$45	Buy

2-Bromo-4-butanolide Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Liquid

Uses

Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1.

Synthesis

96-48-0

5061-21-2

General procedure for the synthesis of α-bromo-γ-butyrolactone from γ-butyrolactone (bromination step): in a 1000 mL reaction vessel equipped with a stirring device, refluxing device, thermometer, dropping funnel, and nitrogen introduction tube, 200 g (2.32 mol) of γ-butyrolactone and 2.76 g (0.086 mol based on 3.7 mol% of γ-butyrolactone) of sulfur were added as the catalyst. 431 g (2.70 mol) of bromine was loaded into a dropping funnel. Stirring was initiated, the reaction temperature was controlled not to exceed 40 °C, and the bromine was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was raised to about 90 °C and the reaction was maintained at this temperature for 1 hour. Subsequently, the temperature was raised to about 110°C and the reaction was continued for 3 hours.

References

[1] Patent: JP5837752, 2015, B2. Location in patent: Paragraph 0052; 0079-0081; 0082; 0085; 0086; 0088
[2] Journal of Porphyrins and Phthalocyanines, 2010, vol. 14, # 1, p. 89 - 100
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3074 - 3077
[4] Synlett, 2005, # 17, p. 2648 - 2652
[5] Organic Letters, 2011, vol. 13, # 14, p. 3670 - 3673

2-Bromo-4-butanolide synthesis

Synthesis of 2-Bromo-4-butanolide from Gamma Butyrolactone

2-Bromo-4-butanolide Preparation Products And Raw materials

Raw materials

Bromine Gamma Butyrolactone

Preparation Products

SPIZOFURONE 2-Oxotetrahydrofuran-3-yl methacrylate ALPHA-HEXYL-GAMMA-BUTYROLACTONE

2-Bromo-4-butanolide Suppliers

Global( 405)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8749	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3590	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3374	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Anhui Yiao New Material Technology Co., Ltd	+86-18033737140 +86-17354101231	sales1@hbganmiao.com	China	227	58
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	283	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20126	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504	sales8@hbganmiao.com	China	300	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
RongNa Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Anhui Yiao New Material Technology Co., Ltd	58
Xiamen Wonderful Bio Technology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Hebei Ganmiao New material Technology Co., LTD	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from 2-Bromo-4-butanolide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-12	2-Bromo-4-butanolide 5061-21-2	US $1.00 / g	1g	99%	1000kg	RongNa Biotechnology Co.,Ltd
2026-03-06	2-Bromo-4-butanolide 5061-21-2	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-01-19	2-Bromo-4-butanolide 5061-21-2	US $0.00 / kg	1kg	0.99	10T	Shandong Hanjiang Chemical Co., Ltd

2-Bromo-4-butanolide
5061-21-2
US $1.00 / g
99%
RongNa Biotechnology Co.,Ltd

2-Bromo-4-butanolide
5061-21-2
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Bromo-4-butanolide
5061-21-2
US $0.00 / kg
0.99
Shandong Hanjiang Chemical Co., Ltd

2-Bromo-4-butanolide Spectrum

2-Bromo-4-butanolide(5061-21-2)MS 2-Bromo-4-butanolide(5061-21-2)¹HNMR 2-Bromo-4-butanolide(5061-21-2)¹³CNMR 2-Bromo-4-butanolide(5061-21-2)IR1 2-Bromo-4-butanolide(5061-21-2)Raman

5061-21-2(2-Bromo-4-butanolide)Related Search:

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A-BROMO-A-TRIFLUOROACETYL-G-BUTYROLACTONE, HYDRATE SALOR-INT L132004-1EA

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2-BROMO-GAMMA-BUTYROLACTONE 2-BROMO-Y-BUTYROLACTONE 2-bromo-4-butanolide 2-BROMO-4-HYDROXYBUTYRIC ACID GAMMA-LACTONE 2-BROMO-4-HYDROXYBUTYRIC ACID LACTONE BROMO(ALPHA-)-GAMMA-BUTYROLACTONE 2-Bromo-4-butyrolactone 2-Bromobutyrolactone 3-bromodihydro-2(3h)-furanon 3-Bromodihydro-2(3H)-furanone 3-Bromodihydro-2-furanone alpha-Bromobutyric acid, gamma-lactone alpha-Bromobutyrolactone -Bromo-butyrolactone A-BROMO-GAMMA-BUTYROLACTONE A-BROMO-G-BUTYROLACTONE AKOS 23 ALPHA-BROMO-GAMMA-BUTYROLACETONE ALPHA-BROMO-GAMMA-BUTYROLACTONE __bromo-r-butyrolactone 2(3H)-Furanone, 3-bromodihydro- 2-Bromo-4-hydroxybutyric acid g-lactone 3-Bromo-4,5-dihydro-2(3H)-furanone alpha-Bromo-gamma-butyrolactone, remainder gamma-butyrolactone alpha-Bromo-gama-butyrolactone 2-Bromo-c-butyrolactone A-BROMO-γ-BUTYROLATONE Alpha-Bromo-Gamma-Butyrolactone95+% Alpha-Bromo-Gama-Butyrolatone alpha-Bromo-gamma-butyrolactone,97% alpha-Bromo-gamma-butyrolactone, ca. 90% à-bromo- A-BROMO--BUTYROLACTONE A-BROMO-R-BUTYROLATONE ɑ-Bromo-γ-butyrolactone, 97% NSC 11726 NSC 56959 3-Bromo-2-furanone ^a-Bromo-^y-butyrolactone, 97% α-Bromo-γ-butyrolactone,2-Bromo-4-hydroxybutyric acid γ-lactone 3-Bromo-dihydro-furan-2-one |á-Bromo-|-butyrolactone α-Bromo-γ-butyrolatone Alpha-BroMo-GaMMa-ButyrolaCLone 2-broMo-4-hydroxybutan-1-ide alpha-Bromo-gamma-butyrolactone 97% 2-Bromo-γ-butyrolactone for synthesis 2-Bromo-4-hydroxybutyric acid 2-Bromo-4-butanolide in stock Factory 3-Bromodihydrofuran-2(3H)-one 95+% α-Bromo-γ-butyroL α-Bromo-γ-butyrolactone> α-Bromo-γ-butanolide 3-Bromodihydrofuran-2(3H)-one 3-Bromotetrahydrofuran-2-one 3-Bromdihydrofuran-2(3H)-on α-Bromo-γ-butyrolactone α-Bromo-γ-butyrolactone