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ChemicalBook CAS DataBase List Atracurium besylate

Atracurium besylate synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1: 92 percent / 2 h / 190 - 210 °C
2: phosphoryl chloride / toluene / 3 h / Heating
3: 71 percent / sodium borohydride / 19 h / Ambient temperature
4: 51 percent / benzene / 48 h / Heating
5: 85 percent / acetonitrile / 48 h / Ambient temperature

References:

Stenlake;Waigh;Dewar;et al. [European Journal of Medicinal Chemistry,1981,vol. 16,# 6,p. 515 - 524]

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