ChemicalBook CAS DataBase List Basifungin

Basifungin synthesis

4synthesis methods

Product Name:Basifungin
CAS Number:127785-64-2
Molecular formula:C60H92N8O11
Molecular Weight:1101.42

L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-methyl-, 2-methyl-1-[(phenylmethoxy)carbonyl]butyl ester, [R-(R*,R*)]- (9CI)

182205-77-2
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127785-64-2
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Yield:-

Steps:

Multi-step reaction with 8 steps
1: H₂ / Pd/C
2: N-methylmorpholine (NMM), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (Bop-Cl)
3: 50percent TFA / CH₂Cl₂
6: H₂ / 10percent Pd/C
7: 1.) 50percent TFA; 2.) 1N HCl / 1.) CH₂Cl₂
8: benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP), DMAP / CH₂Cl₂

References:

Jao, Edwin;Cooper, Alan B.;Rane, Dinanath F.;Saksena, Anil K.;Desai, Jagdish;Wang, James;Girijavallabhan, Viyyoor M.;Ganguly, Ashit K. [Tetrahedron Letters,1996,vol. 37,# 32,p. 5661 - 5664]

13734-34-4
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127785-64-2
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References

102507-13-1 Synthesis

N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

102507-13-1
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$43.00/100mg

127785-64-2
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References

81135-38-8 Synthesis

81135-38-8
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127785-64-2
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References

Basifungin Related Search:

Anidulafungin

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