Benomyl synthesis

Yield:17804-35-2 95.3%

Reaction Conditions:

in 1,2-dichloro-ethane at 20 - 55; for 3.5 h;Temperature;Solvent;

Steps:

5 Example 5
To a 500 mL four-necked flask equipped with a stirrer, a thermometer and a reflux condenser was added carbendazim 39 g (98%, 0.20 mol) at room temperature.Dichloroethane 195 g, stirred for 15 min. n-Butyl isocyanate 26 g (99%, 0.26 mol) was added and stirred for 15 min. Warming,The reaction was incubated at 55 °C for 3 h. Cool down, stir at 0°C for 30min, filter,dry. Benomyl 57.6 g, content 96.0% (yield 95.3%),

References:

Hunan Guofa Fine Chemical Technology Co., Ltd.;Chen Rugui;Lv Zhongxian;Zhu Junjie;Gong Bingyan CN107857733, 2018, A Location in patent:Paragraph 0012-0022

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