ChemicalBook CAS DataBase List Methylparaben

Methylparaben synthesis

14synthesis methods

Product Name:Methylparaben
CAS Number:99-76-3
Molecular formula:C8H8O3
Molecular Weight:152.15

Produced by the methanol esterification of p-hydroxybenzoic acid in the presence of sulfuric acid. The materials are heated for distillation in a glass-lined reactor under reflux. The acid is then neutralized with caustic soda and the product is crystallized by cooling. The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

67-56-1 Synthesis

67-56-1
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123-08-0 Synthesis

123-08-0
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99-76-3
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Yield:99-76-3 99.3%

Reaction Conditions:

with oxygen at 80; under 3750.38 Torr; for 4 h;Sealed tube;Temperature;Reagent/catalyst;Pressure;

Steps:

1-5 Example 4

(1) In a stainless steel jacketed pressure batch reactor, adding a ratio of p-hydroxybenzaldehyde to methanol of 1:100, and adding a nano-cobalt supported Ce_xMe_1-xO₂ solid solution catalyst with [Rpy]+ [PF6]- The mass ratio of the ionic liquid is 1:10. After the reaction device is sealed,First, oxygen was introduced to 0.5 MPa, the oxygen flow rate was 10 mol/min, and then the circulating water bath was heated at a temperature of 80 ° C, stirring was started, and the reaction was started. After the reaction for 4 hours, the intake and the agitation were stopped, the heating was turned off, the circulating cold water was introduced, and the temperature was lowered to vent the air.(2) The reaction solution is poured into a clean single-mouth flask, and excess methanol is distilled off by vacuum distillation, and the remaining portion is poured into a beaker, and an appropriate amount of 2 to 10% sodium carbonate solution is added Cooling and crystallization, the obtained white solid can be washed with deionized water.Drying yields pure methylparaben.The yield of methylparaben was determined to be 99.3 %.

References:

CN110105207,2019,A Location in patent:Paragraph 0016-0030

Benzoic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, methyl ester

133642-20-3
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99-76-3
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References

32122-11-5
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$15.00/5mg

99-76-3
724 suppliers
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References

methyl 4-(trifluoromethylsulfonyloxy)benzoate

17763-71-2
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99-76-3
724 suppliers
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References

115022-65-6
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99-76-3
724 suppliers
$5.00/25g

References

Methylparaben Related Search:

4-Aminophenol Acetonitrile Methyl acetate Phenol Phenol Red p-Hydroxybenzoic acid ethyl ester sodium salt Paraquat dichloride Propylparaben Sodium methylparaben Methanol