Benzene, 1-fluoro-4-(2-propynyloxy)- (9CI) synthesis
4synthesis methods
- Product Name:Benzene, 1-fluoro-4-(2-propynyloxy)- (9CI)
- CAS Number:124700-26-1
- Molecular formula:C9H7FO
- Molecular Weight:150.15
Yield:124700-26-1 98%
Reaction Conditions:
Stage #1: 4-Fluorophenolwith potassium carbonate in N,N-dimethyl-formamide at 20; for 0.5 h;Inert atmosphere;
Stage #2: propargyl bromide in N,N-dimethyl-formamide at 20; for 10 h;Inert atmosphere;
References:
Tsuzuki, Yasuhiro;Nguyen, Thao Kim Nu;Garud, Dinesh R.;Kuberan, Balagurunathan;Koketsu, Mamoru [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 24,p. 7269 - 7273] Location in patent:supporting information; experimental part
