BENZENE,1-METHYL-2-[(4-METHYL) synthesis
- Product Name:BENZENE,1-METHYL-2-[(4-METHYL)
- CAS Number:21895-17-0
- Molecular formula:C15H16
- Molecular Weight:196.29
Yield:21895-17-0 95%
Reaction Conditions:
with C23H40Br2N2NiO5P;magnesium in tetrahydrofuran at 60; for 12 h;Inert atmosphere;
Steps:
27 Example 27: Reduction and cross-coupling reaction of o-methylfluorobenzene and p-methylchlorobenzyl catalyzed by Ni(NHC)[P(OR)3]X2 (R = CH2CH3, X = Br) as catalyst
Under the protection of argon gas, the catalyst (6.8 mg, 0.010 mmol, 2 mol%), magnesium dust (14.5 mg, 0.6 mmol), andO-methylfluorobenzene (55 μl, 0.5 mmol), p-methylchlorobenzyl (80 μl, 0.6 mmol),Tetrahydrofuran (1.0 ml) was used as a solvent, and the reaction was performed at 60 oC for 12 hours.The reaction was terminated with a saturated ammonium chloride solution. The reaction product was extracted with ethyl acetate and purified by column chromatography (with petroleum ether as the developing solvent) with a yield of 95%.
References:
CN110305171,2019,A Location in patent:Paragraph 0077-0078
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