Benzonitrile, 4-(2,2-difluoroacetyl)- synthesis
- Product Name:Benzonitrile, 4-(2,2-difluoroacetyl)-
- CAS Number:1176519-89-3
- Molecular formula:C9H5F2NO
- Molecular Weight:181.14
179184-61-3
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1176519-89-3
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Yield: 70%
Reaction Conditions:
Stage #1:4,4,4-trifluoro-1-[4-(cyano)phenyl]-butane-1,3-dione with Selectfluor in acetonitrile at 90; for 3 h;Inert atmosphere;
Stage #2: with water in acetonitrile for 0.25 h;Inert atmosphere;Reflux;
Stage #3: with triethylamine in acetonitrile at 20; for 16 h;Inert atmosphere;regioselective reaction;
References:
Leng, Daniel J.;Black, Conor M.;Pattison, Graham [Organic and Biomolecular Chemistry,2016,vol. 14,# 5,p. 1531 - 1535] Location in patent:supporting information
