BENZYL 2,2,2-TRICHLOROACETIMIDATE synthesis

Yield:81927-55-1 100%

Reaction Conditions:

with 1,8-diazabicyclo[5.4.0]undec-7-ene in n-heptane at 0; for 0.25 h;Solvent;

Steps:

Synthesis of Bn-TCAI (1) at a 1 g scale
To a suspension of BnOH (1.00 g, 9.28 mmol) and Cl3CCN (1.47 g, 10.2 mmol) in heptane (23 mL) was added DBU(141 mg, 926 μmol) at 0 °C. After the suspension changed to be a solution (actual reaction time = 15 min), heptane (23mL) and saturated aq NH4Cl (23 mL) were added to the reaction mixture. The separated heptane layer was washed withsaturated aq NH4Cl (23 mL). The general drying procedure gave Bn-TCAI (1) (2.34 g, 100%) as colorless oil. The NMRspectra of 1 were in good agreement with the literature data.1

References:

Ikeuchi, Kazutada;Murasawa, Kentaro;Yamada, Hidetoshi [Synlett,2019,vol. 30,# 11,p. 1308 - 1312] Location in patent:supporting information

FullText