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1311317-42-6

BENZYL 3-(CHLOROSULFONYL)PIPERIDINE-1-CARBOXYLATE synthesis

5synthesis methods
-

Yield:-

Reaction Conditions:

with water;chlorine in dichloromethane at 0; for 3.5 h;

Steps:

6.3 Step 3 : benzyl 3-(chlorosulfonyl)piperidine-l-carboxylate

To a solution of Compound 6-3 (2.1 g, 7.15 mmol, 1.0 eq) in CH2CI2 (40 mL) was added water (8 mL) at 0°C and the reaction mixture was bubbled through chlorine gas for 3.5 hours. TLC (petroleum ether/EtOAc 5: 1) showed most of Compound 6-3 was consumed. The organic layer was separated and dried over Na SO . filtered. The filtrate was used for the next step directly as a solution.

References:

WO2020/58913,2020,A1 Location in patent:Page/Page column 51-52