ChemicalBook CAS DataBase List Betahistine

Betahistine synthesis

13synthesis methods

Product Name:Betahistine
CAS Number:5638-76-6
Molecular formula:C8H12N2
Molecular Weight:136.19

100-69-6
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593-51-1 Synthesis

593-51-1
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5638-76-6
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$20.00/250mg

Yield:5638-76-6 95%

Reaction Conditions:

in water at 170; under 7500.75 Torr;Temperature;Pressure;Solvent;

Steps:

1-2; 13-46; 1-7

1. Take 15mL of 2-vinylpyridine without dilution; 2. Take methylamine hydrochloride (9.12g, 135mmol), add water to dissolve it until the solution is 15mL, and use this as reaction solution 1 and reaction solution 2 to wait for feeding. . Adjust the back pressure valve to control the pressure of the reaction system to 1.0 MPa, and connect a section of pre-cooling pipeline with a length of 2 m at the front end of the back pressure valve. The temperature of the heater is controlled to reach 170°C, and the two materials are pumped into the microchannel reactor through the mixer. The reaction liquid 1 fluid flows through the microreactor at 0.5 mL/min, and the reaction liquid 2 fluid flows through the microreactor at 0.9 mL/min. The molar ratio of 2-vinylpyridine to methylamine hydrochloride was 1:1.7, the reaction residence time was 1.8min, and the conversion rate of 2-vinylpyridine was 100% and the selectivity was 95%. %, the yield is 95%, and the product is betahistine.

References:

CN113444034,2021,A Location in patent:Paragraph 0046-0052; 0067-0176;

100-69-6
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$14.00/1mL

74-89-5 Synthesis