C-(1-METHYL-PIPERIDIN-2-YL)-METHYLAMINE synthesis
- Product Name:C-(1-METHYL-PIPERIDIN-2-YL)-METHYLAMINE
- CAS Number:5298-72-6
- Molecular formula:C7H16N2
- Molecular Weight:128.22
38435-64-2
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Yield:5298-72-6 31%
Reaction Conditions:
with lithium aluminium tetrahydride at 0 - 50;Inert atmosphere;
Steps:
49.2 Intermediate STEP 2 :
To a solution of 1-methylpiperidine-2-carboxamide (600mg, 0.70mmol, 1.0eq) was added LiAIH4 (1M, 12.6ml_, 3. Oeq) at 0°C and the mixture was stirred at 50°C under N2 overnight. The reaction was quenched with a minimum amount of water, dried over sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography to give 1-methylpiperidine-2- carboxamide; (170mg, 31%).UPLC-MS (ES+, Method C): 0.34 min, m/z 129.2 [M+H]+
References:
WO2021/152149,2021,A1 Location in patent:Paragraph 000150
41115-30-4
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5298-72-6
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$79.00/250mg