ChemicalBook CAS DataBase List Calcitriol

Calcitriol synthesis

10synthesis methods

Product Name:Calcitriol
CAS Number:32222-06-3
Molecular formula:C27H44O3
Molecular Weight:416.64

4-Cyclohexene-1,3-diol, 5-ethynyl-4-methyl-, (1R,3S)-

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Yield:-

Steps:

Multi-step reaction with 5 steps
1: 14.6 g / imidazole / dimethylformamide / 16 h / Ambient temperature
2: 84 percent / diethylamine, CuI, bispalladium(II) acetate / dimethylformamide / 1.5 h / Ambient temperature
3: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 21 h / Ambient temperature
4: 90 percent / H₂, quinoline / Lindlar catalyst / methanol; hexane / 0.33 h
5: acetone-d6 / 80.3 °C / var. temp.; kinetics, E(a), ΔG(excit.), ΔH(excit.), ΔS(excit.)

References:

Curtin;Okamura [Journal of the American Chemical Society,1991,vol. 113,# 18,p. 6958 - 6966]

140710-96-9 Synthesis