Carbamimidic acid butyl ester synthesis
1synthesis methods
- Product Name:Carbamimidic acid butyl ester
- CAS Number:57536-14-8
- Molecular formula:C5H12N2O
- Molecular Weight:116.16
Yield:57536-14-8 61.7%
Reaction Conditions:
with trifluoroacetic acid at 25; for 12 h;
Steps:
29.1 The first step: the preparation of butyl carbamate
The raw material cyanamide (85.0g, 2.02mol, 1.0eq) was dissolved in n-butanol (80mL), trifluoroacetic acid (231g, 2.02mol, 1.0eq) was added at 25°C, and the reaction mixture was stirred at 25°C for 12h. After the completion of the reaction detected by TLC (DCM:MeOH=10:0), the reaction solution was concentrated to obtain the target compound (145 g, 61.7%).
References:
WO2022/161420,2022,A1 Location in patent:Page/Page column 90