CEP-32496 (free base) synthesis
- Product Name:CEP-32496 (free base)
- CAS Number:1188910-76-0
- Molecular formula:C24H22F3N5O5
- Molecular Weight:517.46
![3-[(6,7-dimethoxy-4-quinazolinyl)oxy]aniline](/CAS/20180629/GIF/1188908-37-3.gif)
1188908-37-3
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![[5-(2,2,2-TRIFLUORO-1,1-DIMETHYL-ETHYL)-ISOXAZOL-3-YL]-CARBAMIC ACID PHENYL ESTER](/CAS/GIF/1188911-77-4.gif)
1188911-77-4
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1188910-76-0
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Yield: 96%
Reaction Conditions:
with dmap in Isopropyl acetate at 70; for 9 h;Inert atmosphere;
Steps:
Preparation from Form A0
To a 10 L Chemglass jacketed reactor with N2 inlet/outlet was added compound 2 (200.0 g, 637 mmol), compound 3 (177.0 g, 596 mmol) and 4-Dimethylaminopyridine (DMAP) (2.88 g) followed by 4.0 L of isopropyl acetate. The internal temperature was raised to 70°C and heated for 9 hours. The reaction remained a slurry throughout there action and HPLC showed no compound 2 remaining after heating for that period. Next,2.0 L of heptane were added at 70°C and the reaction cooled to 20°C. The solids were stirred for lhour, filtered and the cake washed with 2.0 L of 1:1 isopropyl acetate/ heptanes. The white solids were placed in an oven with N2 bleed at 55°C under 75 mbar vacuum. The resulting solids weighed 295 g (96% yield) of Form A0 with 99.3 % purity by HPLC.
References:
CEPHALON, INC.;BIERLMAIER, Stephen J.;HALTIWANGER, Ralph C.;JACOBS, Martin J. WO2014/164648, 2014, A2 Location in patent:Paragraph 23
1188908-37-3
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1000210-73-0
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1188910-76-0
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$35.00/500μg
889940-13-0
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1188910-76-0
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1188911-72-9
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$45.00/50mg
1188910-76-0
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1188911-74-1
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1188910-76-0
97 suppliers
$35.00/500μg