CEP-32496 (free base)
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- $44 - $2300
- Product name: CEP-32496 (free base)
- CAS: 1188910-76-0
- MF: C24H22F3N5O5
- MW: 517.46
- EINECS:
- MDL Number:MFCD22124524
- Synonyms:CEP-32496 (free base);1-[3-[(6,7-Dimethoxyquinazolin-4-yl)oxy]phenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl]urea;Urea, N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-;AC 013773;AC013773;AC-013773. Agerafenib;CEP-32496 FREE BASE;AC013773; AC 013773; AC-013773. AGERAFENIB;1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea
28 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- TRC
Package
- 10mM(in 1mL DMSO)
- 500μg
- 1mg
- 5mg
- 10mg
- 50mg
- 75mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2310AH
- Product description1-[3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea
- Packaging1mg
- Price$131
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2310AH
- Product description1-[3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea
- Packaging5mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2310AH
- Product description1-[3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea
- Packaging10mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA144993
- Product descriptionCEP-32496 98+%
- Packaging1mg
- Price$46
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA144993
- Product descriptionCEP-32496 98+%
- Packaging5mg
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA144993
- Product descriptionCEP-32496 98+%
- Packaging10mg
- Price$107
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA144993
- Product descriptionCEP-32496 98+%
- Packaging50mg
- Price$181
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA144993
- Product descriptionCEP-32496 98+%
- Packaging100mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA144993
- Product descriptionCEP-32496 98+%
- Packaging250mg
- Price$465
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA144993
- Product descriptionCEP-32496 98+%
- Packaging1g
- Price$1162
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0017252
- Product descriptionCEP-32496 95.00%
- Packaging5MG
- Price$459.8
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1413
- Product descriptionCEP-32496
- Packaging10mM(in 1mL DMSO)
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0212
- Product descriptionCEP-32496
- Packaging1mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0212
- Product descriptionCEP-32496
- Packaging5mg
- Price$129
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0212
- Product descriptionCEP-32496
- Packaging10mg
- Price$203
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC103316
- Product descriptionCEP 32496
- Packaging10mg
- Price$225
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2310AH | 1-[3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea | 1mg | $131 | 2021-12-16 | Buy |
| AK Scientific | 2310AH | 1-[3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea | 5mg | $235 | 2021-12-16 | Buy |
| AK Scientific | 2310AH | 1-[3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea | 10mg | $320 | 2021-12-16 | Buy |
| Ambeed | A144993 | CEP-32496 98+% | 1mg | $46 | 2021-12-16 | Buy |
| Ambeed | A144993 | CEP-32496 98+% | 5mg | $77 | 2021-12-16 | Buy |
| Ambeed | A144993 | CEP-32496 98+% | 10mg | $107 | 2021-12-16 | Buy |
| Ambeed | A144993 | CEP-32496 98+% | 50mg | $181 | 2021-12-16 | Buy |
| Ambeed | A144993 | CEP-32496 98+% | 100mg | $235 | 2021-12-16 | Buy |
| Ambeed | A144993 | CEP-32496 98+% | 250mg | $465 | 2021-12-16 | Buy |
| Ambeed | A144993 | CEP-32496 98+% | 1g | $1162 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0017252 | CEP-32496 95.00% | 5MG | $459.8 | 2021-12-16 | Buy |
| ApexBio Technology | A1413 | CEP-32496 | 10mM(in 1mL DMSO) | $165 | 2021-12-16 | Buy |
| Apolloscientific | BISN0212 | CEP-32496 | 1mg | $88 | 2021-12-16 | Buy |
| Apolloscientific | BISN0212 | CEP-32496 | 5mg | $129 | 2021-12-16 | Buy |
| Apolloscientific | BISN0212 | CEP-32496 | 10mg | $203 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC103316 | CEP 32496 | 10mg | $225 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :≥25.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :A crystalline solid
CAS DataBase Reference :1188910-76-0
solubility :≥25.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :A crystalline solid
CAS DataBase Reference :1188910-76-0
Safety Information
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Description
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. CEP-32496 is a potent inhibitor of B-RafV600E (Kd = 14 nM in an in vitro binding assay). It blocks B-RafV600E-dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC50s = 78 and 60 nM, respectively). CEP-32496 binds kinases other than B-Raf but displays selective cytotoxicity for cells expressing B-RafV600E. It displays good oral bioavailability in rats, dogs, and monkeys and has single oral dose pharmacodynamics inhibition of both pMEK and pERK in B-RafV600E colon carcinoma xenografts in nude mice.More related product prices
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