Cetilistat Intermediate synthesis
- Product Name:Cetilistat Intermediate
- CAS Number:890655-08-0
- Molecular formula:C25H41NO4
- Molecular Weight:419.6
2941-78-8
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Yield:890655-08-0 92.3%
Reaction Conditions:
with pyridine in dichloromethane at 20;Cooling with ice;Solvent;Reagent/catalyst;
Steps:
1 Example 1 Preparation of Compound C
In 500mL three-necked flask, disperse compound A (15.1g) in 250mL dichloromethane. Under stirring, add the compound B (30.5g). Under ice-water bath, add pyridine (16.1 mL) to the system. Dropping was completed. Naturally rise room temperature and react .TLC (n-hexane: ethyl acetate: acetic acid = 5:1:0.1) monitored the progress of the reaction, the reaction is complete, add 80mL washed with water, an appropriate amount of the aqueous layer was extracted with methylene chloride, the organic layers combined, dilute hydrochloric acid was added to the system pH was adjusted to 1-2, at ice bath (0-10 deg.C) stirring the precipitated solid was suction filtered, washing the filter cake, the filter cake was rinsed methylene chloride, 40 deg.C blast drying to give 38.7g white solid, yield 92.3%.
References:
CN105669585,2016,A Location in patent:Paragraph 0051; 0052; 0053
2941-78-8
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36653-82-4
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