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1-Hexadecanol

1-Hexadecanol
1-Hexadecanol structure
CAS No.
36653-82-4
Chemical Name:
1-Hexadecanol
Synonyms
ETHAL;Cetal;Ethol;adol52;adol54;lanolc;CETANOL;aldol54;alfol16;atalcoc
CBNumber:
CB4853561
Molecular Formula:
C16H34O
Formula Weight:
242.44
MOL File:
36653-82-4.mol

1-Hexadecanol Properties

Melting point:
49-51 °C
Boiling point:
344 °C
Density 
0.818 g/mL at 25 °C(lit.)
vapor density 
8.34 (vs air)
vapor pressure 
<0.01 mm Hg ( 43 °C)
refractive index 
nD79 1.4283
FEMA 
2554 | 1-HEXADECANOL
Flash point:
275 °F
storage temp. 
2-8°C
solubility 
Soluble in alcohol, chloroform, ether
form 
Powder, Flakes or Pellets
color 
White to off-white
explosive limit
8%
Water Solubility 
insoluble
Merck 
14,2028
JECFA Number
114
BRN 
1748475
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference
36653-82-4(CAS DataBase Reference)
NIST Chemistry Reference
1-Hexadecanol(36653-82-4)
EPA Substance Registry System
1-Hexadecanol(36653-82-4)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  38-36/37/38
Safety Statements  22-24/25-37
WGK Germany  -
RTECS  MM0225000
Autoignition Temperature 483 °F
TSCA  Yes
HS Code  29051700
Hazardous Substances Data 36653-82-4(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

1-Hexadecanol price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 258741 1-Hexadecanol ReagentPlus , 99% 36653-82-4 1g $10.2 2018-11-13 Buy
Sigma-Aldrich 1103003 Cetyl alcohol United States Pharmacopeia (USP) Reference Standard 36653-82-4 100mg $386 2018-11-13 Buy
TCI Chemical H0071 1-Hexadecanol >98.0%(GC) 36653-82-4 25g $18 2018-11-22 Buy
TCI Chemical H0071 1-Hexadecanol >98.0%(GC) 36653-82-4 500g $55 2018-11-22 Buy
Alfa Aesar A11180 1-Hexadecanol, 98% 36653-82-4 2500g $93.3 2018-11-13 Buy

1-Hexadecanol Chemical Properties,Uses,Production

Description

1-Hexadecanol is odorless.

Chemical Properties

1-Hexadecanol is odorless.

Chemical Properties

white solid

Chemical Properties

Cetyl alcohol occurs as waxy, white flakes, granules, cubes, or castings. It has a faint characteristic odor and bland taste.

Occurrence

Reported as a major constituent of spermaceti oil, where it is present chiefy as cetyl palmitate Also reported found in guava, peach, pear, kohlrabi, baked potato, mustard, Parmesan cheese, butter, milk powder, boiled egg, cooked chicken, roasted beef, beef fat, whiskies, tea, starfruit, mango, rice, licorice, kiwifruit, loquat, endive, shrimp, crab, clam, Cape gooseberry and pawpaw

Uses

Pharmaceutic aid (emulsifying and stiffening agent).

Uses

cetyl alcohol is a versatile ingredient that can serve as an emollient, emulsifier, thickener, binder, foam booster, or emulsion stabilizer, depending on the formulation and need. It is derived from coconut or palm oil as well as being synthetically manufactured. It is considered by some sources to be a non-comedogenic material.

Definition

ChEBI: A long chain fatty alcohol that is hexadecane substituted by a hydroxy group at position 1.

Production Methods

Cetyl alcohol may be manufactured by a number of methods such as esterification and hydrogenolysis of fatty acids or by catalytic hydrogenation of the triglycerides obtained from coconut oil or tallow. Cetyl alcohol may be purified by crystallization and distillation.

Pharmaceutical Applications

Cetyl alcohol is widely used in cosmetics and pharmaceutical formulations such as suppositories, modified-release solid dosage forms, emulsions, lotions, creams, and ointments.
In suppositories cetyl alcohol is used to raise the melting point of the base, and in modified-release dosage forms it may be used to form a permeable barrier coating. In lotions, creams, and ointments cetyl alcohol is used because of its emollient, water-absorptive, and emulsifying properties. It enhances stability, improves texture, and increases consistency. The emollient properties are due to absorption and retention of cetyl alcohol in the epidermis, where it lubricates and softens the skin while imparting a characteristic ‘velvety’ texture.
Cetyl alcohol is also used for its water absorption properties in water-in-oil emulsions. For example, a mixture of petrolatum and cetyl alcohol (19 : 1) will absorb 40–50% of its weight of water. Cetyl alcohol acts as a weak emulsifier of the water-in-oil type, thus allowing a reduction of the quantity of other emulsifying agents used in a formulation. Cetyl alcohol has also been reported to increase the consistency of water-in-oil emulsions.
In oil-in-water emulsions, cetyl alcohol is reported to improve stability by combining with the water-soluble emulsifying agent. The combined mixed emulsifier produces a close packed, monomolecular barrier at the oil–water interface which forms a mechanical barrier against droplet coalescence.
In semisolid emulsions, excess cetyl alcohol combines with the aqueous emulsifier solution to form a viscoelastic continuous phase that imparts semisolid properties to the emulsion and also prevents droplet coalescence. Therefore, cetyl alcohol is sometimes referred to as a ‘consistency improver’ or a ‘bodying agent’, although it may be necessary to mix cetyl alcohol with a hydrophilic emulsifier to impart this property.
It should be noted that pure or pharmacopeial grades of cetyl alcohol may not form stable semisolid emulsions and may not show the same physical properties as grades of cetyl alcohol that contain significant amounts of other similar alcohols.

Safety

Cetyl alcohol is mainly used in topical formulations, although it has also been used in oral and rectal preparations.
Cetyl alcohol has been associated with allergic delayed-type hypersensitivity reactions in patients with stasis dermatitis. Crosssensitization with cetostearyl alcohol, lanolin, and stearyl alcohol has also been reported. It has been suggested that hypersensitivity may be caused by impurities in commercial grades of cetyl alcohol since highly refined cetyl alcohol (99.5%) has not been associated with hypersensitivity reactions.
LD50 (mouse, IP): 1.6 g/kg
LD50 (mouse, oral): 3.2 g/kg
LD50 (rat, IP): 1.6 g/kg
LD50 (rat, oral): 5 g/kg

storage

Cetyl alcohol is stable in the presence of acids, alkalis, light, and air; it does not become rancid. It should be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise the alcohol from aqueous EtOH or from cyclohexane. Alternatively purify it by zone refining. The purity can be checked by gas chromatography. [Beilstein 1 H 429, 1 I 219, 1 II 466, 1 III 1815, 1 IV 1876.]

Incompatibilities

Incompatible with strong oxidizing agents. Cetyl alcohol is responsible for lowering the melting point of ibuprofen, which results in sticking tendencies during the process of film coating ibuprofen crystals.

Regulatory Status

Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules and tablets, otic and rectal preparations, topical aerosols, creams, emulsions, ointments and solutions, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

1-Hexadecanol Preparation Products And Raw materials

Raw materials

Preparation Products


1-Hexadecanol Suppliers

Global( 286)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21759 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1849 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23964 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28237 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8260 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 848 58

View Lastest Price from 1-Hexadecanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-16 1-Hexadecanol
36653-82-4
US $1.00 / KG 1KG 98% 500kg career henan chemical co

1-Hexadecanol Spectrum


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