(4,4-difluorocyclohexyl)methanamine synthesis
- Product Name:(4,4-difluorocyclohexyl)methanamine
- CAS Number:810659-05-3
- Molecular formula:C7H13F2N
- Molecular Weight:149.18
922728-21-0
70 suppliers
inquiry
810659-05-3
60 suppliers
$45.00/25mg
Yield: 87%
Reaction Conditions:
with hydrogen;Raney 2800 nickel in ethanol;water under 2585.81 Torr;Product distribution / selectivity;
Steps:
[(4,4-Difluorocyclohexyl)methyl]amineRaney 2800 nickel, slurry in water, active catalyst (6 mL) was added to a solution of 4,4-difluorocyclohexanecarbonitrile (18.2 g, 125 mmol) in EtOH (300 mL). The reaction mixture was shaken overnight in a Parr hydrogenation apparatus under a 50 PSI atmosphere of hygrogen. The reaction mixture was filtered over a celite pad and the solvent was concentrated to provide the title compound as a colorless liquid. Yield 16 g (87%). 1H NMR (400 MHz, CHLOROFORM-D): δ 1.17 - 1.46 (m, 3 H), 1.52 - 1.94 (m, 2 H), 2.03 - 2.32 (m, 2 H), 2.57 - 2.70 (m, 2 H).
References:
ASTRAZENECA AB WO2007/13848, 2007, A1 Location in patent:Page/Page column 10
927209-98-1
32 suppliers
$45.00/25mg
810659-05-3
60 suppliers
$45.00/25mg
809273-64-1
13 suppliers
inquiry
810659-05-3
60 suppliers
$45.00/25mg
![8,8-difluoro-1,4-dioxaspiro[4.5]decane](/CAS/20150408/GIF/176251-49-3.gif)
176251-49-3
51 suppliers
$8.00/250mg
60-29-7
0 suppliers
$30.00/50g
22515-18-0
246 suppliers
$5.00/100mg
810659-05-3
60 suppliers
$45.00/25mg
1122648-78-5
2 suppliers
inquiry
810659-05-3
60 suppliers
$45.00/25mg