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898759-78-9

CYCLOHEXYL 3-(1,3-DIOXOLAN-2-YL)PHENYL KETONE synthesis

1synthesis methods
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Yield:898759-78-9 78%

Reaction Conditions:

Stage #1: 3-(1,3-dioxolan-2-yl)-phenylbromidewith diisobutylaluminum chloride in tetrahydrofuran at -78;Inert atmosphere;Schlenk technique;
Stage #2: with n-butyllithium in tetrahydrofuran;hexane at -78 - 20;Inert atmosphere;Schlenk technique;
Stage #3: cyclohexanylcarbonyl chloridewith copper(I) cyanide di(lithium chloride) in tetrahydrofuran;hexane at -40 - 25;Inert atmosphere;

References:

Klatt, Thomas;Groll, Klaus;Knochel, Paul [Chemical Communications,2013,vol. 49,# 62,p. 6953 - 6955] Location in patent:supporting information