CYCLOHEXYL 3-(1,3-DIOXOLAN-2-YL)PHENYL KETONE synthesis
- Product Name:CYCLOHEXYL 3-(1,3-DIOXOLAN-2-YL)PHENYL KETONE
- CAS Number:898759-78-9
- Molecular formula:C16H20O3
- Molecular Weight:260.33
17789-14-9
148 suppliers
$6.00/1g
2719-27-9
359 suppliers
$16.00/25mL
898759-78-9
11 suppliers
$417.00/1g
Yield:898759-78-9 78%
Reaction Conditions:
Stage #1: 3-(1,3-dioxolan-2-yl)-phenylbromidewith diisobutylaluminum chloride in tetrahydrofuran at -78;Inert atmosphere;Schlenk technique;
Stage #2: with n-butyllithium in tetrahydrofuran;hexane at -78 - 20;Inert atmosphere;Schlenk technique;
Stage #3: cyclohexanylcarbonyl chloridewith copper(I) cyanide di(lithium chloride) in tetrahydrofuran;hexane at -40 - 25;Inert atmosphere;
References:
Klatt, Thomas;Groll, Klaus;Knochel, Paul [Chemical Communications,2013,vol. 49,# 62,p. 6953 - 6955] Location in patent:supporting information