DIMETHYL 2-(4-CYANO-2-NITROPHENYL)MALONATE synthesis
- Product Name:DIMETHYL 2-(4-CYANO-2-NITROPHENYL)MALONATE
- CAS Number:651747-69-2
- Molecular formula:C12H10N2O6
- Molecular Weight:278.22
Yield:651747-69-2 88%
Reaction Conditions:
Stage #1: malonic acid dimethyl esterwith potassium tert-butylate in dimethyl sulfoxide at 20;
Stage #2: 4-chloro-3-nitrobenzonitrile in dimethyl sulfoxide at 20 - 100;
References:
Roth, Gerald J.;Heckel, Armin;Colbatzky, Florian;Handschuh, Sandra;Kley, J?rg;Lehmann-Lintz, Thorsten;Lotz, Ralf;Tontsch-Grunt, Ulrike;Walter, Rainer;Hilberg, Frank [Journal of Medicinal Chemistry,2009,vol. 52,# 14,p. 4466 - 4480] Location in patent:experimental part
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