DL-3-(2-thienyl)-beta-alanine synthesis
- Product Name:DL-3-(2-thienyl)-beta-alanine
- CAS Number:18389-46-3
- Molecular formula:C7H9NO2S
- Molecular Weight:171.2169
Yield:18389-46-3 72%
Reaction Conditions:
with ammonium acetate in ethanol; for 7 h;Reflux;
Steps:
1 Synthesis of Compound 1-2
Compound 1-1 (2.00 g, 17.83 mmol) was dissolved in 5.5 mL of ethanol, to which was successively added ammonium acetate (2.74 g, 35.58 mmol) and malonic acid (1.85 g, 17.78 mmol). The reaction was kept with stirring and refluxed for 7 hours. White turbidity appeared in the clear reaction solution. Then the reaction mixture was filtered and washed with hot ethanol (3×10 mL) to give white solids 1-2 (2.20 g, yield 72%), MS: 172.0 [M+H]+.
References:
US2017/44187,2017,A1 Location in patent:Paragraph 0086; 0092
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