ChemicalBook CAS DataBase List DL-Alanine

DL-Alanine synthesis

12synthesis methods

Product Name:DL-Alanine
CAS Number:302-72-7
Molecular formula:C3H7NO2
Molecular Weight:89.09

Anthrobacter oxydans HAP-1 hyper produces DL-alanine in a nongrowth-associated manner.

127-17-3 Synthesis

127-17-3
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849585-22-4 Synthesis

849585-22-4
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302-72-7
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Yield:302-72-7 90.8 %Spectr. ，849585-22-4 9.2 mg

Reaction Conditions:

with [pentamethylcyclopentadienyl*Ir(N-phenyl-2-pyridinecarboxamidate)Cl];ammonium formate in methanol at 37; for 6 h;chemoselective reaction;Solvent;

Steps:

General Procedure for Reductive Amination of α-Ketoacids

General procedure: α-Ketoacid (0.2 mmol) and Ir1 (1 mol%) were added to a 1.5-dram vial equipped with amagnetic stir bar in methanol (1 mL). Solid HCOONH4 (2 mmol, 10 equiv.) was added to thevial and the solution was stirred at 37 °C for 6 h. The precipitate was filtered, washed with asmall amount of cold methanol, and dried under vacuum to give the desired α-amino acid.

References:

Nguyen, Dat P.;Sladek, Rudolph N.;Do, Loi H. [Tetrahedron Letters,2020,vol. 61,# 32,art. no. 152196] Location in patent:supporting information

113-24-6 Synthesis