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Pyruvic acid

CAS No.
127-17-3
Chemical Name:
Pyruvic acid
Synonyms
2-OXOPROPANOIC ACID;Propanoic acid, 2-oxo-;pyruvic;CH3COCOOH;2-oxo-propanoicaci;NSC 179;FEMA 2970;PYRUVIC ACID;Pyruvia Acid;ACID PYRUVATE
CBNumber:
CB5257557
Molecular Formula:
C3H4O3
Lewis structure
c3h4o3 lewis structure
Molecular Weight:
88.06
MDL Number:
MFCD00002585
MOL File:
127-17-3.mol
MSDS File:
SDS
Last updated:2024-06-12 17:09:27

Pyruvic acid Properties

Melting point 11-12 °C (lit.)
Boiling point 165 °C (lit.)
Density 1.267 g/mL at 25 °C (lit.)
vapor pressure 1.72hPa at 25℃
refractive index n20/D 1.428(lit.)
FEMA 2970 | PYRUVIC ACID
Flash point 183 °F
storage temp. 2-8°C
solubility Miscible with chloroform and methanol.
pka 2.39(at 25℃)
form Liquid
color Clear colorless to light yellow or amber
PH 3.11(1 mM solution);2.38(10 mM solution);1.79(100 mM solution);
Odor at 1.00 % in propylene glycol. sharp sour acetic caramellic
Odor Type acidic
Merck 14,8021
JECFA Number 936
BRN 506211
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. Refrigerate.
InChIKey LCTONWCANYUPML-UHFFFAOYSA-N
LogP -1.24
Dissociation constant 2.49 at 25℃
Substances Added to Food (formerly EAFUS) PYRUVIC ACID
FDA 21 CFR 172.515
CAS DataBase Reference 127-17-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 8558G7RUTR
NIST Chemistry Reference Pyruvic acid(127-17-3)
EPA Substance Registry System Propanoic acid, 2-oxo- (127-17-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P301+P330+P331-P303+P361+P353-P305+P351+P338
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45-25-27
RIDADR  UN 3265 8/PG 2
WGK Germany  3
RTECS  UZ0829800
Autoignition Temperature 305 °C
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29335995
NFPA 704
1
3 0

Pyruvic acid price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W297070 Pyruvic Acid natural, ≥95%, FG 127-17-3 25g $99.4 2024-03-01 Buy
Sigma-Aldrich W297070 Pyruvic Acid natural, ≥95%, FG 127-17-3 100g $227 2024-03-01 Buy
Sigma-Aldrich W297070 Pyruvic Acid natural, ≥95%, FG 127-17-3 1kg $1510 2024-03-01 Buy
Sigma-Aldrich W297003 Pyruvic Acid ≥97%, FG 127-17-3 250g $97.2 2024-03-01 Buy
Sigma-Aldrich W297003 Pyruvic Acid ≥97%, FG 127-17-3 1kg $163 2024-03-01 Buy
Product number Packaging Price Buy
W297070 25g $99.4 Buy
W297070 100g $227 Buy
W297070 1kg $1510 Buy
W297003 250g $97.2 Buy
W297003 1kg $163 Buy

Pyruvic acid Chemical Properties,Uses,Production

Uses

Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.

Antioxidant effect

Studies have shown that pyruvic acid can inhibit the oxidation of oxygen free radicals in mice, and as a hydrogen peroxide scavenger, it has the effect of preventing free radical damage, and it has been proved to be protective in cardiac reperfusion injury and acute renal failure. The body resists functional damage. Pyruvic acid can act as an antioxidant through two mechanisms: first, as an α-keto acid, pyruvic acid can directly inhibit hydrogen peroxide through a non-enzymatic decarbonation reaction; second, supplementation of pyruvic acid can enhance In the citric acid cycle, after the production of citric acid increases, the phosphofructokinase is inhibited, thereby entering the pentose phosphate bypass to generate reduced coenzyme II (NADPH), thereby indirectly increasing the ability of the glutathione (GSH) antioxidant system. Pyruvic acid can also increase the ratio of coenzyme I/reduced coenzyme I (NAD+/NADH) and promote the reaction of the tricarboxylic acid cycle.

Chemical Properties

Colorless to light yellow liquid

Chemical Properties

Pyruvic acid has a sour, acetic odor (similar to acetic acid). It has a pleasant, sour taste with a burning, somewhat sweet note. It tends to darken and decompose unless kept free of minor contaminants and in tightly sealed containers

Occurrence

Isolated from cane sugar fermentation broth and from a few plants; also reported found in peppermint, raw asparagus, leaves and stalk of celery, onion, rutabaga, milk, cream, buttermilk, wheaten bread, blue cheeses, cheddar cheese, cottage cheese, provolone cheese, yogurt, beef, Virginia tobacco, beer, white wine, botrytised wine, cocoa and sake.

Uses

pyruvic acid is an alpha hydroxy acid that can be irritating and is considered difficult to work with. It has a larger molecular size than the most commonly used AHAs. Sodium pyruvate is more commonly used, and is an organic salt.

Uses

Pyruvic acid is used as a component in culture broths and media as commercial red seaweed polysaccharide. It is involved in the construction of amino acid alanine as well as supplies energy to living cells via citric acid cycle (Krebs cycle). It reacts with N-acetyl mannosamine by an aldol-type condensation to prepare sialic acid. It is employed to study the cultivation of soil bacteria as micro colonies using soil substrate membrane system. It finds application in liquid chromatography and in the determination of organic acids in red wine.

Preparation

By distillation of tartaric acid in the presence of potassium acid sulfate as a dehydrating agent; from acetyl chloride and potassium cyanide to yield the nitrile, which is subsequently acid hydrolyzed to the acid; pyruvic acid must be rectified under vacuum.

Definition

Pyruvic acid is an important organic chemical intermediate, an intermediate compound in the metabolism of carbohydrates, proteins, and fats, and is used in a variety of fields, including the pharmaceutical, cosmetic, food, and chemical industries. It has roles as a basic metabolite and cofactor. In thiamine deficiency, its oxidation is retarded and it tends to accumulate in neurostructural tissues causing neurological damage. In vitro studies have shown that pyruvic acid modulates cardiac function at physiological or low doses, but can cause cardiomyocyte damage at high doses.

Aroma threshold values

Aroma characteristics at 1.0%: acidic, sweet, caramellic and sour.

Taste threshold values

Taste characteristics at 5 ppm: sharp acidic, sour fruity, with sour creamy and caramellic nuances.

General Description

Pyruvic acid is the key component formed during the hydrolysis of flavor-precursors called S-alk(en)yl-L-cysteine-sulfoxides in onion tissues by allinase during maceration or chopping. The amount of pyruvic acid formed is used as a measure for onion pungency.

Biochem/physiol Actions

Taste at 5 ppm

Biotechnological Applications

Pyruvic acid is a key position in cell metabolism and is involved in many catabolic and anabolic pathways, including glycolysis, gluconeogenesis, amino acid, and protein metabolism. Pyruvic acid is employed for the production of L-tryptophan, L-tyrosine, and 3,4-dihydroxyphenyl alanine in various industries. The diet supplementation with pyruvic acid increased fat loss and minimized the associated loss of body protein. Pyruvic acid is also used in biochemical researches and medicine as a substrate for assaying activities of such enzymes as pyruvate dehydrogenase, pyruvate carboxylase, and pyruvate decarboxylase (Nakazawa et al. 1972; Yamada et al. 1972; Stanko et al. 1992).
Y. lipolytica oxidize glucose and form pyruvic acid (75–80 %) and a-ketoglutaric acid (20–25 %) under thiamine deficiency conditions. The synthesis of the acid was triggered by a decrease in intracellular thiamine concentration to 3.0 lg per 1 g biomass. An approximately 3-fold increase in the amount of the biomass was associated with a subsequent decrease in thiamine content to the level of 1.0 lg per 1 g biomass, whose maximum production of pyruvic acid was 50 g/L in this condition. In addition to glucose, thiamine-auxotrophic yeasts are capable of synthesizing pyruvic acid when grown on glycerol and propionic acid. Technicalgrade glycerol is the most promising raw material for pyruvic acid production. Pyruvic acid was obtained at a concentration of 61 g/L with a yield of 71 % from glycerol (Morgunov et al. 2004; Finogenova et al. 2005).

Purification Methods

Distil it twice, then fractionally crystallise it by partial freezing. [Beilstein 3 IV 1505.]

849585-22-4
127-17-3
Synthesis of Pyruvic acid from 2-Hydroxypropanoic acid
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View Lastest Price from Pyruvic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pyruvic acid pictures 2024-06-21 Pyruvic acid
127-17-3
US $0.30 / g 1g 99% 300tons Hebei Dangtong Import and export Co LTD
Pyruvic acid pictures 2024-06-21 Pyruvic acid
127-17-3
US $23.00-10.00 / g 1g 99% 8000g Hebei Dangtong Import and export Co LTD
Pyruvic acid pictures 2024-06-12 Pyruvic acid
127-17-3
US $6.00 / KG 1KG 99% 2000KG/Month Hebei Saisier Technology Co., LTD
  • Pyruvic acid pictures
  • Pyruvic acid
    127-17-3
  • US $0.30 / g
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • Pyruvic acid pictures
  • Pyruvic acid
    127-17-3
  • US $23.00-10.00 / g
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • Pyruvic acid pictures
  • Pyruvic acid
    127-17-3
  • US $6.00 / KG
  • 99%
  • Hebei Saisier Technology Co., LTD
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