(E)-3-Hepten-2-one synthesis
- Product Name:(E)-3-Hepten-2-one
- CAS Number:5609-09-6
- Molecular formula:C7H12O
- Molecular Weight:112.17
Yield:-
Reaction Conditions:
with sodium hydroxide in ethanol;water at 0 - 20;
Steps:
4.2. General procedure for the synthesis of compounds (2a-o)
General procedure: The aldehyde (10 mmol) was added gradually to a solution of NaOH (0.5 g) in H2O (10.0 mL) and ketone (10 mmol) in ethanol (15 mL) at 0 °C. The mixture was then allowed to warm to room temperature and stirred for overnight. At the end of this period, KHSO4 (1 N) solution was added to the flask until pH~6, followed by extraction with ether. The combined organic layers were dried over Na2SO4 and concentrated to give a solid, which was purified by flash column chromatography using EtOAc/petroleum ether at last.
References:
Shi, Jian;Liu, Yangbin;Wang, Min;Lin, Lili;Liu, Xiaohua;Feng, Xiaoming [Tetrahedron,2011,vol. 67,# 10,p. 1781 - 1787] Location in patent:supporting information; experimental part
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