1-(5-aMino-2-fluorophenyl)ethanone synthesis
- Product Name:1-(5-aMino-2-fluorophenyl)ethanone
- CAS Number:67500-19-0
- Molecular formula:C8H8FNO
- Molecular Weight:153.15
79110-05-7
67500-19-0
General procedure for the synthesis of 2-fluoro-5-aminoacetophenone from 1-(2-fluoro-5-nitrophenyl)ethanone: 1-(2-fluoro-5-nitrophenyl)ethanone (0.3 g, 1.64 mmol), iron powder (0.27 g, 4.92 mmol), ammonium chloride (0.17 g, 3.28 mmol), isopropanol (12.8 mL), and water (3.2 mL ) were mixed and reacted for 3 hours. After completion of the reaction, the insoluble precipitate was removed by filtration, the organic layer was extracted with dichloromethane, dried with anhydrous magnesium sulfate, and concentrated in vacuum to obtain a yellow oily crude product. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1:2, Rf=0.3) to afford 2-fluoro-5-aminoacetophenone (0.19 g, 76% yield).
445-27-2
477 suppliers
$9.00/25g
67500-19-0
73 suppliers
$35.35/250mgs:
Yield:-
Steps:
Multi-step reaction with 2 steps
1: 55 percent / conc. H2SO4; HNO3 / -15 °C
2: 57 percent / H2 / Pt(S)/C / ethanol / 2585.74 Torr
References:
Wu, Yong-Jin;He, Huan;Sun, Li-Qiang;Wu, Dedong;Gao, Qi;Li, Hui-Yin [Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,# 10,p. 1725 - 1728]
79110-05-7
163 suppliers
$20.00/5g
67500-19-0
73 suppliers
$35.35/250mgs:
400-93-1
228 suppliers
$14.00/5g
67500-19-0
73 suppliers
$35.35/250mgs:
99-03-6
407 suppliers
$6.00/10g
67500-19-0
73 suppliers
$35.35/250mgs: