ethyl 1-(3-chlorophenyl)-1H-pyrazole-4-carboxylate synthesis

5synthesis methods

Product Name:ethyl 1-(3-chlorophenyl)-1H-pyrazole-4-carboxylate
CAS Number:110821-32-4
Molecular formula:C12H11ClN2O2
Molecular Weight:250.68

ETHYL 5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE

15001-08-8
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$28.60/250mg

ethyl 1-(3-chlorophenyl)-1H-pyrazole-4-carboxylate

110821-32-4
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Yield:110821-32-4 80%

Reaction Conditions:

with isopentyl nitrite in tetrahydrofuran; for 24 h;Reflux;

References:

Corte, James R.;Pinto, Donald J. P.;Fang, Tianan;Osuna, Honey;Yang, Wu;Wang, Yufeng;Lai, Amy;Clark, Charles G.;Sun, Jung-Hui;Rampulla, Richard;Mathur, Arvind;Kaspady, Mahammed;Neithnadka, Premsai Rai;Li, Yi-Xin Cindy;Rossi, Karen A.;Myers, Joseph E.;Sheriff, Steven;Lou, Zhen;Harper, Timothy W.;Huang, Christine;Zheng, Joanna J.;Bozarth, Jeffrey M.;Wu, Yiming;Wong, Pancras C.;Crain, Earl J.;Seiffert, Dietmar A.;Luettgen, Joseph M.;Lam, Patrick Y. S.;Wexler, Ruth R.;Ewing, William R. [Journal of Medicinal Chemistry,2020,vol. 63,# 2,p. 784 - 803] Location in patent:supporting information

80370-42-9 Synthesis