ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate synthesis
- Product Name:ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate
- CAS Number:68809-64-3
- Molecular formula:C8H12N2O2
- Molecular Weight:168.19
67-56-1
776 suppliers
$9.00/25ml
856061-38-6
16 suppliers
inquiry
68809-64-3
24 suppliers
$220.00/100mg
Yield:68809-64-3 76.38%
Reaction Conditions:
with di-isopropyl azodicarboxylate;triphenylphosphine in tetrahydrofuran at 0 - 25; for 5 h;Inert atmosphere;
Steps:
206.1 Step 1: ethyl l,4-dimethyl-lH-pyrazole-5-carboxylate
Into a 100-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed ethyl 4-methyl-lH-pyrazole-5-carboxylate (3 g, 19.46 mmol, 1 equiv.), DIAD (7.9 g, 38.92 mmol, 2 equiv.), THF (30 mL), and MeOH (3.1 g, 97.30 mmol, 5 equiv.), and ΡΡ1 (10.2 g, 38.92 mmol, 2 equiv.) was added at 0 °C. The resulting solution was stirred for 5 h at 25°C and then concentrated under vacuum. The residue was applied onto a silica gel column and eluted with ethyl acetate/petroleum ether (1 :50) to give the title compound as a yellow liquid in76.38% yield.
References:
WO2019/18562,2019,A1 Location in patent:Paragraph 0695
856061-38-6
16 suppliers
inquiry
74-88-4
351 suppliers
$15.00/10g
68809-64-3
24 suppliers
$220.00/100mg
856061-38-6
16 suppliers
inquiry
74-88-4
351 suppliers
$15.00/10g
68809-64-3
24 suppliers
$220.00/100mg
68809-65-4
34 suppliers
$130.00/50mg
121781-57-5
6 suppliers
inquiry
68809-64-3
24 suppliers
$220.00/100mg