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ETHYL 1,5-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLATE synthesis

8synthesis methods
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Yield:53561-07-2 90%

Reaction Conditions:

Stage #1: ethyl 3-oxo-3-phenylpropionatewith N,N-dimethyl-formamide dimethyl acetal in toluene; for 4 h;Reflux;
Stage #2: phenylhydrazine hydrochloridewith hydrogenchloride in butan-1-ol; for 16 h;Reflux;

References:

?enica, Luka;Stopar, Karmen;Friedrich, Miha;Gro?elj, Uro?;Plavec, Janez;Po?kaj, Marta;Podlipnik, ?rtomir;?tefane, Bogdan;Svete, Jurij [Journal of Organic Chemistry,2016,vol. 81,# 1,p. 146 - 161]