ethyl-3-(diMethylaMino)-2-(phenylcarbonyl)prop-2-enoate synthesis
- Product Name:ethyl-3-(diMethylaMino)-2-(phenylcarbonyl)prop-2-enoate
- CAS Number:66129-60-0
- Molecular formula:C14H17NO3
- Molecular Weight:247.29
Yield:66129-60-0 100%
Reaction Conditions:
at 110; for 0.666667 h;Microwave irradiation;
Steps:
149.a
Example 149.;
() Anti- [2- (benzylmethylamino)-4-phenylpyrimidin-5-yl]- [2- (hydroxyphenylmethyl) piperidin-1-yl]methanone (I) Ar =phenyl, X = Me (C6H5CH2) N, R and Y together- (CH2) 4-, R2= R3 = R4 = H (Table 12.); a) Ethyl (2-benzoyl-3-dimethylamino) acrylate (V) (Herrero, M. T. et al., Tetrahedron 2002,58 (42), 8581-8589; The mixture of ethyl benzoylacetate (25g, 117 mmol) and N,N-dimethylformamide dimethyl acetal (18.2 ml, 128 mmol) is stirred at 110°C in microwave reactor (50W) for 40 minutes. After evaporation in vacuum 29 g (100 %) of the title compound is obtained, which is used without further purification. LC/MS: [MH+] 248.3 (Cl4Hl7NO3 247.292)
References:
WO2005/75458,2005,A1 Location in patent:Page/Page column 52
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