ethyl 1-acetylcyclopropanecarboxylate synthesis
- Product Name:ethyl 1-acetylcyclopropanecarboxylate
- CAS Number:32933-03-2
- Molecular formula:C8H12O3
- Molecular Weight:156.18
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32933-03-2
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Yield:32933-03-2 78.1 g (65.1%)
Reaction Conditions:
with potassium carbonate in acetone;
Steps:
R.11.1 Ethyl 1-acetylcyclopropanecarboxylate
Referential Example 11-1 Ethyl 1-acetylcyclopropanecarboxylate Ethyl acetoacetate (100 g, 0.77 mol) was dissolved in acetone (500 ml). To the thus obtained solution was added dibromoethane (361 g, 1.92 mol) and potassium carbonate (266 g, 1.92 mol) and the mixture was heated under reflux for 4 days. After filtering off insoluble matter, the filtrate was distilled under reduced pressure (80° C./8 mmHg) to obtain 78.1 g (65.1%) of the title compound as a colorless oily substance. 1 H-NMR (400 MHz, CDCl3) δ: 1.29 (3H, t, J=7.33 Hz), 1.47 (4H, s), 2.47 (3H, s), 4.21 (2H, q, J=7.33 Hz).
References:
US6121285,2000,A
141-97-9
814 suppliers
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106-93-4
402 suppliers
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32933-03-2
116 suppliers
$41.00/250mg
141-97-9
814 suppliers
$5.00/25g
107-06-2
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32933-03-2
116 suppliers
$41.00/250mg
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141-97-9
814 suppliers
$5.00/25g
32933-03-2
116 suppliers
$41.00/250mg
141-97-9
814 suppliers
$5.00/25g
106-93-4
402 suppliers
$15.00/5g
2986-03-0
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32933-03-2
116 suppliers
$41.00/250mg