ChemicalBook CAS DataBase List Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate synthesis

7synthesis methods

Product Name:Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
CAS Number:2199-51-1
Molecular formula:C9H13NO2
Molecular Weight:167.21

4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid

5442-91-1
112 suppliers
$25.00/500mg

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

2199-51-1
238 suppliers
$7.00/250mg

Yield:2199-51-1 98.5%

Reaction Conditions:

Inert atmosphere;Temperature;

Steps:

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate (8)
4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (7, 5.0 g, 25.0 mmol) was heated in a flask to 200-210 °C with an oil bath for 12 min. The reactant gradually melted with accompanying production of carbon dioxide. The heating was removed when there was no more gas evolving. The reaction was allowed to cool down to r.t. and then dried under vacuum to afford 8 as a pale-gray solid (3.90 g, 98.5 %), m.p. 75-76 °C (lit. 74-76 °C [17]), yield 90.0 % (lit. [13]). R_f = 0.73 (eluent: chloroform/methanol, v/v = 10:1).

References:

Meng, Ge;Liu, Chunyan;Qin, Shidong;Dong, Mengshu;Wei, Xiaomi;Zheng, Meilin;Qin, Liwen;Wang, Huihui;He, Xiaoshuang;Zhang, Zhiguo [Research on Chemical Intermediates,2015,vol. 41,# 11,p. 8941 - 8954]

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