Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate synthesis
- Product Name:Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
- CAS Number:2199-51-1
- Molecular formula:C9H13NO2
- Molecular Weight:167.21
5442-91-1
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$25.00/500mg
2199-51-1
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$7.00/250mg
Yield:2199-51-1 98.5%
Reaction Conditions:
Inert atmosphere;Temperature;
Steps:
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate (8)
4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (7, 5.0 g, 25.0 mmol) was heated in a flask to 200-210 °C with an oil bath for 12 min. The reactant gradually melted with accompanying production of carbon dioxide. The heating was removed when there was no more gas evolving. The reaction was allowed to cool down to r.t. and then dried under vacuum to afford 8 as a pale-gray solid (3.90 g, 98.5 %), m.p. 75-76 °C (lit. 74-76 °C [17]), yield 90.0 % (lit. [13]). Rf = 0.73 (eluent: chloroform/methanol, v/v = 10:1).
References:
Meng, Ge;Liu, Chunyan;Qin, Shidong;Dong, Mengshu;Wei, Xiaomi;Zheng, Meilin;Qin, Liwen;Wang, Huihui;He, Xiaoshuang;Zhang, Zhiguo [Research on Chemical Intermediates,2015,vol. 41,# 11,p. 8941 - 8954]
86770-31-2
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$19.78/1gm:
2199-51-1
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$7.00/250mg
2436-79-5
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$16.00/1 / G
2199-51-1
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$7.00/250mg
817162-41-7
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2199-51-1
247 suppliers
$7.00/250mg
141-97-9
816 suppliers
$5.00/25g
2199-51-1
247 suppliers
$7.00/250mg