ETHYL 2-(5-CHLORO-2-NITROPHENYL)-2-CYANOACETATE synthesis

Yield:-

Reaction Conditions:

with potassium tert-butylate in tetrahydrofuran; for 48 h;Reflux;

Steps:

1

3.1.Ethyl 2-(5-chloro-2-nitrophenyl)-2-cyanoacetate (5): Compound 5 was prepared from 2,4-dichloronitrobenzene (3) (6 g, 31.3 mmol) and ethyl cyanoacetate (6.66 ml, 2 equiv, 62.6 mmol) according to literature conditions.13 Compound 5 was obtained as a dark oil. The oil was purified by column chromatography (hexane/EtOAc 0-10% EtOAc). 1H NMR is in agreement with literature.18 The crude material was used directly for the next step.

References:

Tichy, Michal;Pohl, Radek;Hocek, Michal;Xu, Hao Ying;Chen, Yen-Liang;Yokokawa, Fumiaki;Shi, Pei-Yong [Bioorganic and medicinal chemistry,2012,vol. 20,# 20,p. 6123 - 6133,11]