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ChemicalBook CAS DataBase List ethyl 2-(6-aminopyridin-3-yl)acetate
1174229-72-1

ethyl 2-(6-aminopyridin-3-yl)acetate synthesis

4synthesis methods
52092-47-4 Synthesis
5-Chloro-2-nitropyridine

52092-47-4
355 suppliers
$6.00/1g

-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C
1.2: 4 h / 80 °C
2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
3.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

References:

MERCK SHARP & DOHME CORP.;DONG, Shuzhi;PASTERNAK, Alex;SUZUKI, Takao;GU, Xin;FU, Qinghong;JIANG, Jinlong;DING, Fa-Xiang;TANG, Haifeng;DEJESUS, Reynalda K. WO2015/96035, 2015, A1

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