ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE synthesis
- Product Name:ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE
- CAS Number:54368-61-5
- Molecular formula:C7H5Cl2N3O4
- Molecular Weight:266.04
52047-16-2
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54368-61-5
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Yield: 94%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine;trichlorophosphate at 100; for 5 h;Reagent/catalyst;
Steps:
1.3; 2.3; 3.3; 4.3
3) 150 grams of nitroorotate, 1500 grams of phosphorus oxychloride and 600 grams of diisopropylethylamine are mixed and subjected to a chlorination reaction at 100 ° C for 5 hours. Concentrated to remove excess phosphorus oxychloride, quenched with water and extracted with organic solvents, dried, and concentratedEthyl 2,4-dichloro-5-nitro-6-pyrimidinecarboxylic acid was obtained and recrystallized163 g of pure product was obtained, with a purity of more than 98%,Yield: 94%;
References:
Nanjing Puruida Pharmaceutical Technology Co., Ltd.;Wang Xiaobo CN110452180, 2019, A Location in patent:Paragraph 0019; 0023; 0025; 0029; 0031; 0035; 0037; 0041
17687-24-0
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54368-61-5
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65-86-1
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16632-21-6
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$5.00/1g
54368-61-5
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