Ethyl 2-cyano-3-hydroxybut-2-enoate synthesis
2synthesis methods
- Product Name:Ethyl 2-cyano-3-hydroxybut-2-enoate
- CAS Number:87853-82-5
- Molecular formula:C7H9NO3
- Molecular Weight:155.15
Yield:87853-82-5 92%
Reaction Conditions:
Stage #1: P-toluenesulfonyl cyanide;ethyl acetoacetatewith potassium carbonate in tetrahydrofuran;water at 20; for 1 h;
Stage #2: with hydrogenchloride in tetrahydrofuran;water at 0; pH=Ca. 2;Further stages;
References:
Akula, Ramulu;Xiong, Yan;Ibrahim, Hasim [RSC Advances,2013,vol. 3,# 27,p. 10731 - 10735]
