ethyl 2-(ethylamino)-2-oxoacetate synthesis
- Product Name:ethyl 2-(ethylamino)-2-oxoacetate
- CAS Number:20943-60-6
- Molecular formula:C6H11NO3
- Molecular Weight:145.16
Yield:20943-60-6 41.3%
Reaction Conditions:
Aliquat 336 in dichloromethane at 20; for 72 h;
Steps:
1
Examples: Example 1: ethyl(ethylamino)(oxo)acetate; To 135,8 ml (1000 mM) of diethyloxalate and 1g of aliquat 336 in 1000 ml of dichloromethane were added 64,4 ml (1000 mM) of ethylamine (70% in water). The reaction mixture was stirred at room temperature for 72h. The reaction mixture was dried over anhydrous sodium sulfate and the solvent was removed under vacuum, to give an oil, wich was further purified by silica gel column chromatography, using dichloromethane/dimethylketone (95/5) as eluant, to give 59,9g of ethyl(ethyl amino)(oxo)acetate as an oil. Yield: 41 ,3%.NMR 1H (300 MHz / DMSO-d6) δ (ppm): 1,06(t,3H), 1 ,28(t,3H), 3,17(m,2H), 4,22(q,2H), 8,92(s,1 H)
References:
WO2009/109259,2009,A1 Location in patent:Page/Page column 28
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20943-60-6
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![Acetic acid, 2-[[(1,1-dimethylethoxy)carbonyl]ethylamino]-2-oxo-, ethyl ester](/CAS/20210305/GIF/216959-38-5.gif)
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20943-60-6
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20943-60-6
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$320.00/1g