Ethyl 2-oxo-2-(thiazol-2-yl)acetate synthesis
- Product Name:Ethyl 2-oxo-2-(thiazol-2-yl)acetate
- CAS Number:33656-63-2
- Molecular formula:C7H7NO3S
- Molecular Weight:185.2
79265-30-8
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Yield:33656-63-2 67%
Reaction Conditions:
in dichloromethane at 20; for 1 h;
Steps:
P
Procedure P: Ethyl 2-oxo-2-(thiazol-2-yl)acetate; To a solution of 5.0 mL (31.3 mmol, 1.0 eq.) of 2-trimethylsilylthiazole in 250 mL Of CH2Cl2 was added 7.0 mL (62.6 mmol, 2 eq.) of ethyl 2-chloro-2-oxoacetate. The reaction mixture was stirred at room temperature for 1 h and the solvent removed in vacuo. The residue was purified by flash chromatography (10% ethyl acetate/hexanes) to provide 3.9 g (21 mmol, 67 %) of ethyl 2-oxo-2-(thiazol-2-yl)acetate as a pale yellow oil. δH, 300 MHz, CDCl3: 1.42 (t, 3H), 4.48 (q, 2H), 7.83 (d, IH), 8.16 (d, IH).
References:
WO2010/8775,2010,A1 Location in patent:Page/Page column 29-30
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