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2-Bromothiazole

Description Referrence
2-Bromothiazole
2-Bromothiazole structure
CAS No.
3034-53-5
Chemical Name:
2-Bromothiazole
Synonyms
TZ-Br;CL028;NSC 91532;2-Bromthiazol;2-BROMOTHIAZOLE;2-bromo-thiazol;2-BROMOTHIOAZOLE;Thiazole, 2-bromo-;2-THIAZOLYL BROMIDE;TIMTEC-BB SBB003918
CBNumber:
CB1739860
Molecular Formula:
C3H2BrNS
Formula Weight:
164.02
MOL File:
3034-53-5.mol

2-Bromothiazole Properties

Melting point:
171 C
Boiling point:
171 °C(lit.)
Density 
1.82 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.593(lit.)
Flash point:
146 °F
storage temp. 
2-8°C
pka
0.84±0.10(Predicted)
form 
Liquid
color 
Clear colorless to orange-brown
Specific Gravity
1.836
Water Solubility 
insoluble
BRN 
105724
InChIKey
RXNZFHIEDZEUQM-UHFFFAOYSA-N
CAS DataBase Reference
3034-53-5(CAS DataBase Reference)
NIST Chemistry Reference
Thiazole, 2-bromo-(3034-53-5)
EPA Substance Registry System
Thiazole, 2-bromo- (3034-53-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H227-H315-H319-H335
Precautionary statements  P210e-P261-P280a-P305+P351+P338-P405-P501a-P210-P280-P403+P235-P501
Hazard Codes  Xi,F
Risk Statements  36/37/38
Safety Statements  23-24/25-36-26
RIDADR  1993
WGK Germany  3
TSCA  Yes
HazardClass  IRRITANT, FLAMMABLE
HS Code  29341000

2-Bromothiazole price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 160474 2-Bromothiazole 98% 3034-53-5 5g $43.1 2019-12-02 Buy
Sigma-Aldrich 160474 2-Bromothiazole 98% 3034-53-5 25g $134 2019-12-02 Buy
TCI Chemical B1280 2-Bromothiazole >98.0%(GC) 3034-53-5 25g $99 2020-06-24 Buy
TCI Chemical B1280 2-Bromothiazole >98.0%(GC) 3034-53-5 250g $594 2020-06-24 Buy
Alfa Aesar A14838 2-Bromothiazole, 99% 3034-53-5 25g $116 2020-06-24 Buy

2-Bromothiazole Chemical Properties,Uses,Production

Description

It is usually used as the intermediate or raw material to produce various products in the organic synthesis and pharmaceutical industry, such as 2-acetylthiazole, antibiotics, and anticholinergic drugs. Specifically, this chemical can act as the raw material to produce camalexin through reaction with indolylmagnesium iodide.1 Moreover, this substance has been selected as the reactant to prepare the thiazole Grignard reagents and thiazolyllithium compounds, which can be converted into thiazole-2-carboxylic acid via a halogen-metal exchange reaction.2, 3 In addition, 2-bromothiazole has been used to synthesize N-aryl aminothiazoles, which are found to function as the inhibitors of cyclin-dependent kinases.4 Besides, this compound may be involved in the synthesis of ethynylthiazoles that exhibits a desirable anti-inflammatory activity.5

Referrence

  1. Ayer, W. A.; Craw, P. A.; Ma, Y. T.; Miao, S. C., SYNTHESIS OF CAMALEXIN AND RELATED PHYTOALEXINS. Tetrahedron 1992, 48, 2919-2924.
  2. Kurkjy, R. P.; Brown, E. V., THE PREPARATION OF THIAZOLE GRIGNARD REAGENTS AND THIAZOLYLLITHIUM COMPOUNDS. J. Am. Chem. Soc. 1952, 74, 6260-6262.
  3. Beyerman, H. C.; Berben, P. H.; Bontekoe, J. S., THE SYNTHESIS OF THIAZOLE-2-CARBOXYLIC AND OF THIAZOLE-5-CARBOXYLIC ACID VIA A HALOGEN-METAL EXCHANGE REACTION. Recl. Trav. Chim. Pays-Bas-J. Roy. Neth. Chem. Soc. 1954, 73, 325-332.
  4. Misra, R. N.; Xiao, H. Y.; Williams, D. K.; Kim, K. S.; Lu, S. F.; Keller, K. A.; Mulheron, J. G.; Batorsky, R.; Tokarski, J. S.; Sack, J. S.; Kimball, D.; Lee, F. Y.; Webster, K. R., Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977.
  5. Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V., Synthesis and anti-inflammatory activity of ethynylthiazoles. Khim. Geterotsiklicheskikh Soedin. 2006, 769-774.

Chemical Properties

Colourless Liquid

Uses

Aryl halide used to N-arylate 5- and 7-azaindoles.1 Copper-catalyzed cyanation provides 2-cyanothiazole.2

Uses

2-Bromothiazole is a heterocyclic S compound to induce base-pair substitution and having mutagenic activity.

2-Bromothiazole Preparation Products And Raw materials

Raw materials

Preparation Products


2-Bromothiazole Suppliers

Global( 323)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
career henan chemical co
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sales@coreychem.com CHINA 30043 58
Biochempartner
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Hubei Jusheng Technology Co.,Ltd.
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027-59599243 linda@hubeijusheng.com CHINA 28231 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19988 58
Xiamen AmoyChem Co., Ltd
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Chongqing Chemdad Co., Ltd
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Wuhan Chemwish Technology Co., Ltd
+86-27-67849912
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Nanjing jinheyou Trading Co., Ltd.
15705188088
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CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58

View Lastest Price from 2-Bromothiazole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-25 2-Bromothiazole
3034-53-5
US $0.00 / g 1g 95%min 20kg/month Nanjing jinheyou Trading Co., Ltd.
2018-12-20 2-Bromothiazole
3034-53-5
US $1.00 / kg 1kg 98%min 1000kg career henan chemical co

2-Bromothiazole Spectrum


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