ethyl 3-oxo-(3-pyrimidin-2-yl)propanoate synthesis
- Product Name:ethyl 3-oxo-(3-pyrimidin-2-yl)propanoate
- CAS Number:1093114-80-7
- Molecular formula:C9H10N2O3
- Molecular Weight:194.19
141-78-6
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Yield:1093114-80-7 85%
Reaction Conditions:
with lithium hexamethyldisilazane in tetrahydrofuran at -40; for 0.333333 h;Inert atmosphere;Claisen condensation;
Steps:
General procedure to synthesis β-keto esters from the corresponding esters
General procedure: To the solution of ester (10 mmol) in THF (20 mL) and ethyl acetate (70 mmol), LiHMDS (30 mmol) was added very quickly at -40 °C, and stirred at this temperature for 20 min. After completion of the reaction, reaction mixture was quenched with acetic acid (50 mmol) and then basified using 10% NaHCO3 solution, extracted with ethyl acetate (2×100 mL), the combined organic layer was washed with water and brine solution and dried over Na2SO4. The specific purification procedure for each compound has been included along with their characterization data.
References:
Venkat Ragavan;Vijayakumar;Rajesh;Palakshi Reddy;Karthikeyan;Suchetha Kumari [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 12,p. 4193 - 4197] Location in patent:supporting information; experimental part
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