ETHYL 4-ACETAMIDOPIPERIDINE-1-CARBOXYLATE synthesis

Yield:208179-77-5 100%

Reaction Conditions:

with sodium hydrogencarbonate in water at 0 - 20;

Steps:

22

EXAMPLE 22; 4-Acetamido-N-ethoxycarbonylpiperdine; A solution of 4-acetamidopiperidine (20.7 g), sodium bicarbonate (10.6 g) and water (300 ml) was cooled to 0°C, and 17.7 g of ethyl chloroformate was added dropwise, with stirring. Upon completion of the addition, the reaction mixture was allowed to warm to ambient temperature and was diluted with water and ethyl acetate. The layers were separated, and the organic layer was washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated to give 32.2 g (100%) of product.

References:

EP892802,2003,B1 Location in patent:Page/Page column 7-8; 18