ethyl 5-bromo-2-(trifluoromethoxy)benzoate synthesis
- Product Name:ethyl 5-bromo-2-(trifluoromethoxy)benzoate
- CAS Number:773135-66-3
- Molecular formula:C10H8BrF3O3
- Molecular Weight:313.07
407-14-7
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$5.00/1g
623-49-4
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$10.60/1gm:
773135-66-3
37 suppliers
$117.00/500mg
Yield:773135-66-3 77%
Reaction Conditions:
Stage #1: 1-bromo-4-(trifluoromethoxy)benzenewith (2,2,6,6-tetramethylpiperidyl)2Mn*2MgCl2*4LiCl in tetrahydrofuran at 25; for 10 h;Inert atmosphere;
Stage #2: ethyl cyanoformate in tetrahydrofuran at 0 - 25;Inert atmosphere;chemospecific reaction;
References:
Wunderlich, Stefan H.;Kienle, Marcel;Knochel, Paul [Angewandte Chemie - International Edition,2009,vol. 48,# 39,p. 7256 - 7260][Angewandte Chemie,2009,vol. 121,# 39,p. 7392 - 7396] Location in patent:supporting information; experimental part