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Ethyl cyanoformate

Ethyl cyanoformate structure

CAS No.: 623-49-4

Chemical Name:: Ethyl cyanoformate

Synonyms: NSC 65347;C2H5OC(O)CN;cyanoformate;ETHYL CYANOFORMATE;Ethylcyanoformate,99%;ethyl carbonocyanidate;Ethyl cyanoformate 99%;Ethoxycarbonyl Cyanide;Ethyl cyanocarboxylate;Ethyl Cyanoformate >

CBNumber:: CB8854001

Molecular Formula:: C4H5NO2

Molecular Weight:: 99.09

MDL Number:: MFCD00001836

MOL File:: 623-49-4.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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Ethyl cyanoformate Properties

Boiling point	115-116 °C (lit.)
Density	1.003 g/mL at 25 °C (lit.)
refractive index	n20/D 1.381(lit.)
Flash point	76 °F
storage temp.	Inert atmosphere,2-8°C
solubility	Miscible with chloroform and methanol.
form	Liquid
Specific Gravity	1.01
color	Clear colorless
Sensitive	Moisture Sensitive
BRN	635955
Exposure limits	NIOSH: IDLH 25 mg/m3
CAS DataBase Reference	623-49-4(CAS DataBase Reference)
FDA UNII	I56GWI2QQ5
NIST Chemistry Reference	NCCOOC2H5(623-49-4)
EPA Substance Registry System	Carbonocyanidic acid, ethyl ester (623-49-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05

Signal word

Danger

Hazard statements

H226-H314

Precautionary statements

P210-P280-P303+P361+P353-P305+P351+P338+P310

Hazard Codes

T,F

Risk Statements

10-23/24/25-34-36/37/38

Safety Statements

26-36/37/39-45-24/25-16-7/9

RIDADR

UN 3275 6.1/PG 2

WGK Germany

10-19-21

TSCA

Yes

HazardClass

6.1

PackingGroup

HS Code

29269090

NFPA 704

	3
1		0

Ethyl cyanoformate price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E18859	Ethyl cyanoformate 99%	623-49-4	10g	$86.5	2024-03-01	Buy
Sigma-Aldrich	E18859	Ethyl cyanoformate 99%	623-49-4	50g	$114	2024-03-01	Buy
TCI Chemical	C1266	Ethyl Cyanoformate >98.0%(GC)	623-49-4	5g	$35	2024-03-01	Buy
TCI Chemical	C1266	Ethyl Cyanoformate >98.0%(GC)	623-49-4	25g	$98	2024-03-01	Buy
Alfa Aesar	L15777	Ethyl cyanoformate, 99%	623-49-4	5g	$39.1	2024-03-01	Buy

Product number	Packaging	Price	Buy
E18859	10g	$86.5	Buy
E18859	50g	$114	Buy
C1266	5g	$35	Buy
C1266	25g	$98	Buy
L15777	5g	$39.1	Buy

Ethyl cyanoformate Chemical Properties,Uses,Production

Chemical Properties

Clear Colourless Liquid

Uses

Ethyl cyanoformate can be used as a cyanide source for the cyanation of:

Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.

Uses

Ethyl Cyanoformate (cas# 623-49-4) is a compound useful in organic synthesis.

Uses

Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.

Application

Ethyl cyanoformate can be used as a cyanide source for the cyanation of:
Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.
Ethyl cyanoformate is a general cyanating agent. It can be used in the nucleophilic addition of cyanide to carbonyl compounds, oxidative cyanation of tertiary amines and in the synthesis of β-cyano-substituted acrylates from alkynes.

Purification Methods

Dissolve the cyanoformate in Et2O, dry it over Na2SO4, filter, evaporate and distil it [Malachowsky et al. Chem Ber 70 1016 1937, Adickes et al. J Prakt Chem [2] 133 313 1932, Grundmann et al. Justus Liebigs Ann Chem 577 77 1952]. [Beilstein 2 IV 1862.]

Precautions

Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Ethyl cyanoformate Preparation Products And Raw materials

Raw materials

Preparation Products

ETHANOL-1,1,2,2-D4-AMINE Ethyl 2-cyclohexyl-2-oxoacetate ETHYL 4-BROMOTHIAZOLE-2-CARBOXYLATE ETHYL 5-PYRIMIDINECARBOXYLATE 98 ETHYL 2-(2-CHLOROPHENYL)ACETATE

ETHOXY-IMINO-ACETIC ACID ETHYL ESTER DIETHYL 4-METHOXYPHENYL MALONATE INDOXYL ACETATE Ethyl benzoylformate ethyl 2,6-difluoro-3-(MethoxyMethoxy)benzoate

ethyl 5-bromo-2-(trifluoromethoxy)benzoate ethyl 4-oxo-3,4-dihydro-2H-1-benzopyran-3-carboxylate Ethyl 2-bromoquinoline-4-carboxylate

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Ethyl cyanoformate Suppliers

Global( 261)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Ethyl cyanoformate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-06-15	Ethyl cyanoformate 623-49-4	US $157.00 / ASSAYS	1KG	99%	10 tons	Baoji Guokang Bio-Technology Co., Ltd.
2022-01-15	EthylCarbonocyanidate 623-49-4	US $0.00 / KG	1KG	97.6%	100 tons	Honest Joy Holdings Limited
2021-07-13	Ethyl cyanoformate 623-49-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Ethyl cyanoformate
623-49-4
US $157.00 / ASSAYS
99%
Baoji Guokang Bio-Technology Co., Ltd.

EthylCarbonocyanidate
623-49-4
US $0.00 / KG
97.6%
Honest Joy Holdings Limited

Ethyl cyanoformate
623-49-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Ethyl cyanoformate Spectrum

Ethyl cyanoformate(623-49-4)MS Ethyl cyanoformate(623-49-4)¹HNMR Ethyl cyanoformate(623-49-4)¹³CNMR Ethyl cyanoformate(623-49-4)IR1 Ethyl cyanoformate(623-49-4)Raman

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Ethyl carbonocyanidoate Ethyl cyanoforMate, 99% 10GR Ethyl cyanoforMate, 99% 50GR ethyl carbonocyanidate Ethyl cyanoforMate, 98%+ Ethyl cyanoformate 99% CYANOFORMIC ACID ETHYL ESTER ETHYL CYANOFORMATE 2-ethoxy-2-oxoacetonitrile [(Cyanocarbonyl)oxy]ethane C2H5OC(O)CN carbocyanidicacidethylester Carbonocyanidic acid, ethyl ester carbonocyanidicacid,ethylester Formic acid, cyano-, ethyl ester Nitriloaceticacidethylester Ethoxycarbonyl Cyanide NSC 65347 Ethylcyanoformate,99% cyanoformate Ethyl cyanocarboxylate Ethyl Cyanoformate > Formicacid, cyano-, ethyl este 623-49-4 NCCOOC2H5 C4H5NO2 NCCO2C2H5 NCCO2CH2CH3 Esters Organic Building Blocks Building Blocks C2 to C5 Carbonyl Compounds C2 to C5 Carbonyl Compounds Chemical Synthesis Organic Building Blocks Aliphatics Esters C2 to C5 Carbonyl Compounds Building Blocks john's