Ethyl 8-methoxyquinolie-3-carboxylate synthesis
- Product Name:Ethyl 8-methoxyquinolie-3-carboxylate
- CAS Number:71083-22-2
- Molecular formula:C13H13NO3
- Molecular Weight:231.25
27568-05-4
55 suppliers
$56.00/250mg
71083-22-2
29 suppliers
$160.00/25mg
Yield:71083-22-2 99%
Reaction Conditions:
Stage #1: ethyl 4-chloro-8-methoxyquinoline-3-carboxylatewith hydrogen;acetic acid;palladium on activated carbon under 1551.49 Torr; for 2 h;
Stage #2: with triethylamine in dichloromethane; pH=~ 7;
Steps:
83.D
Step D: Ethyl 8-methoxyquinoline-3-carboxylate: Ethyl 4-chloro-8-methoxyquinoline-3-carboxylate (5.5 g, 21 mmol), 10% wt. Pd/C (2.2 g) and HOAc (30 mL) was hydrogenated in a Parr shaker at 30 psi for 2 hours. The Pd was removed by filtration and the filtrate was concentrated. The residue was diluted with dichloromethane (100 mL), water (50 mL) and the pH was adjust to 7 with TEA. The aqueous layer was extracted with dichloromethane. The combined organic layer was dried, filtered and concentrated to give the desired product (4.8 g, 99%).
References:
US2007/49603,2007,A1 Location in patent:Page/Page column 66
10601-80-6
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$6.00/5g
53055-05-3
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$60.00/100mg
71083-22-2
29 suppliers
$160.00/25mg
27568-04-3
84 suppliers
$6.00/250mg
71083-22-2
29 suppliers
$160.00/25mg