Ethyl cyanoglyoxylate-2-oxime synthesis
- Product Name:Ethyl cyanoglyoxylate-2-oxime
- CAS Number:3849-21-6
- Molecular formula:C5H6N2O3
- Molecular Weight:142.11
105-56-6
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3849-21-6
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Yield:3849-21-6 93%
Reaction Conditions:
with glacial acetic acid;NaNO2 at 0 - 20; for 6.66667 h;
Steps:
General procedure for the synthesis of compound 1
A mixture of ethyl cyanoacetate (11.3 g, 0.1 mol) and 45% acetic acid aqueous solution (45 mL) was stirred at 0 °C for 10 min. Within 90 min, sodium nitrite (21.0 g, 0.3 mol) was added in three times. Then, the reaction system was stirred at room temperature for 5 h. The solvent is removed under pressure and the product was dried to give a yellow solid 1 and used without further purification (Yield 93%).
References:
Guo, Hongmei;Nie, Lifei;Bozorov, Khurshed;Aisa, Haji Akber;Zhao, Jiangyu [Heterocycles,2022,vol. 104,# 6,p. 1085 - 1097] Location in patent:supporting information
31124-95-5
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3849-21-6
269 suppliers
$6.00/25g