ETHYL5-CYANO-6-METHYLNICOTINATE synthesis
- Product Name:ETHYL5-CYANO-6-METHYLNICOTINATE
- CAS Number:106944-54-1
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
1118-61-2
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80370-42-9
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Yield:106944-54-1 79%
Reaction Conditions:
Stage #1: ethyl 2-formyl-3-oxopropanoatewith triethylamine in diethyl ether at 0; for 1 h;
Stage #2: with p-toluenesulfonyl chloride in N,N-dimethyl-formamide at -15 - 20;
Stage #3: 3-Aminocrotononitrilewith pyridine in N,N-dimethyl-formamide at 0 - 70; for 10 h;
References:
Hameed P, Shahul;Patil, Vikas;Solapure, Suresh;Sharma, Umender;Madhavapeddi, Prashanti;Raichurkar, Anandkumar;Chinnapattu, Murugan;Manjrekar, Praveena;Shanbhag, Gajanan;Puttur, Jayashree;Shinde, Vikas;Menasinakai, Sreenivasaiah;Rudrapatana, Suresh;Achar, Vijayashree;Awasthy, Disha;Nandishaiah, Radha;Humnabadkar, Vaishali;Ghosh, Anirban;Narayan, Chandan;Ramya;Kaur, Parvinder;Sharma, Sreevalli;Werngren, Jim;Hoffner, Sven;Panduga, Vijender;Kumar, C. N. Naveen;Reddy, Jitendar;Kumar Kn, Mahesh;Ganguly, Samit;Bharath, Sowmya;Bheemarao, Ugarkar;Mukherjee, Kakoli;Arora, Uma;Gaonkar, Sheshagiri;Coulson, Michelle;Waterson, David;Sambandamurthy, Vasan K.;De Sousa, Sunita M. [Journal of Medicinal Chemistry,2014,vol. 57,# 11,p. 4889 - 4905] Location in patent:supporting information
![2-Propenoic acid, 2-formyl-3-[[(4-methylphenyl)sulfonyl]oxy]-, ethyl ester](/CAS/20210305/GIF/861407-17-2.gif)
75894-42-7
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106944-54-1
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87-13-8
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