EW-7197 Hydrochloride synthesis
- Product Name:EW-7197 Hydrochloride
- CAS Number:1352610-25-3
- Molecular formula:C22H19ClFN7
- Molecular Weight:435.89
1352608-82-2
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$70.00/10mg
1352610-25-3
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Yield:1352610-25-3 97%
Reaction Conditions:
with hydrogenchloride in diethyl ether;dichloromethane at 0 - 20; for 0.0833333 h;Inert atmosphere;
Steps:
Synthesis of N-((4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1Himidazol-2-yl)methyl)-2-fluoroaniline hydrochloride (13a·HCl)
To a stirred solution of 13ain CH2Cl2 (1 mL) cooled 0 °C, was added 1.0 M HCl in Et2O (1.9 mL, 1.88 mmol) undernitrogen atmosphere. The mixture was stirred at room temperature for 5 min and evaporated todryness under reduced pressure. The solid was dried using a rotary evaporator in vacuo at 40 °C for 16 h to afford the titled compound as a yellow solid. Yield 97%.
References:
Jin, Cheng Hua;Krishnaiah, Maddeboina;Sreenu, Domalapally;Subrahmanyam, Vura Bala;Park, Hyun-Ju;Park, So-Jung;Sheen, Yhun Yhong;Kim, Dae-Kee [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 9,p. 2724 - 2732] Location in patent:supporting information
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356560-84-4
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![6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine](/CAS/20200515/GIF/1352609-89-2.gif)
1352609-89-2
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1352610-25-3
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![4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde](/CAS/GIF/1352609-91-6.gif)
1352609-91-6
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1352610-25-3
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![Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-](/CAS/GIF/614750-82-2.gif)
614750-82-2
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1352610-25-3
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