EZM-K synthesis
- Product Name:EZM-K
- CAS Number:191330-56-0
- Molecular formula:C24H19F2NO3
- Molecular Weight:407.41
163222-33-1
644 suppliers
$5.00/50mg
191330-56-0
134 suppliers
$265.00/250mg
Yield:191330-56-0 75.7%
Reaction Conditions:
with potassium permanganate in tetrahydrofuran for 5 h;Reflux;Green chemistry;Solvent;Reagent/catalyst;
Steps:
6 Example 4 Preparation of Ketone Impurities
Ezetimibe (1 g, 2.44 mmol) was added to a 50 ml reaction flask, dissolved in 10 ml of tetrahydrofuran, and then potassium permanganate (0.58 g, 3.66 mmol) was added, and the mixture was stirred and heated at reflux for 5 hours. After the reaction of TLC was completed (petroleum ether:ethyl acetate=3:1, V/V), the solid was removed by filtration, and the filtrate was concentrated to dryness at a temperature of 40-50° C. to obtain a red-brown solid. To the solid was added 5 ml of isopropanol and 5 ml of water, stirred and dissolved by warming, and then the mixture was cooled to 0-5 DEG C and crystallized for 1 hour. Filter, filter cake with 2ml water, and drain. The filter cake was collected and dried at 60° C. to obtain 0.75 g of ketone impurities in a yield of 75.7%. 99.5% product purity by HPLC
References:
Hunan Fangsheng Pharmaceutical Co., Ltd.;Zhang Qinghua;Chen Bo;Xu Mi CN107474000, 2017, A Location in patent:Paragraph 0050; 0051
![(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one](/CAS/GIF/190595-65-4.gif)
190595-65-4
190 suppliers
$11.00/250mg
191330-56-0
134 suppliers
$265.00/250mg
![Benzenamine, 4-fluoro-N-[[4-(phenylmethoxy)phenyl]methylene]-, [N(Z)]-](/CAS/20211123/GIF/219653-96-0.gif)
219653-96-0
1 suppliers
inquiry
191330-56-0
134 suppliers
$265.00/250mg
![(3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid](/CAS/GIF/204589-82-2.gif)
204589-82-2
64 suppliers
inquiry
191330-56-0
134 suppliers
$265.00/250mg
204589-84-4
2 suppliers
inquiry
191330-56-0
134 suppliers
$265.00/250mg