FMoc-4-sulfoMethyl-Phe(Tce)-OH synthesis
1synthesis methods
- Product Name:FMoc-4-sulfoMethyl-Phe(Tce)-OH
- CAS Number:1146758-11-3
- Molecular formula:C27H24Cl3NO7S
- Molecular Weight:612.91
![L-Phenylalanine, 4-[[(2,2,2-trichloroethoxy)sulfonyl]methyl]-](/CAS/20210305/GIF/1146758-14-6.gif)
Yield:1146758-11-3 85%
Reaction Conditions:
Stage #1: C12H14Cl3NO5S;(fluorenylmethoxy)carbonyl chloridewith sodium carbonate in 1,4-dioxane; for 20 h;Schotten-Baumann reaction;
Stage #2: with hydrogenchloride in 1,4-dioxane;water; pH=2 - 3;optical yield given as %ee;
References:
Ali, Ahmed M.;Hill, Bryan;Taylor, Scott D. [Journal of Organic Chemistry,2009,vol. 74,# 9,p. 3583 - 3586] Location in patent:experimental part