Fmoc-N-(4-O-tbu)-Phenethyl-Gly-OH synthesis
- Product Name:Fmoc-N-(4-O-tbu)-Phenethyl-Gly-OH
- CAS Number:258332-56-8
- Molecular formula:C29H31NO5
- Molecular Weight:473.56
![Glycine, N-[2-[4-(1,1-dimethylethoxy)phenyl]ethyl]-, ethyl ester](/CAS/20210305/GIF/1286711-12-3.gif)
1286711-12-3
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82911-69-1
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$7.00/25g
258332-56-8
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Yield:258332-56-8 66%
Reaction Conditions:
Stage #1: N-[2-(4-tert-butyloxyphenyl)ethyl]glycine ethyl esterwith sodium hydroxide in methanol; for 0.5 h;Inert atmosphere;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimidewith hydrogenchloride in 1,4-dioxane;water at 0 - 20;Inert atmosphere;
References:
Einsiedel, Jürgen;Held, Cornelia;Hervet, Maud;Plomer, Manuel;Tschammer, Nuska;Hübner, Harald;Gmeiner, Peter [Journal of Medicinal Chemistry,2011,vol. 54,# 8,p. 2915 - 2923] Location in patent:experimental part
157981-64-1
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258332-56-8
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